Tadalafil zeigt eine konstante Resorption im Gastrointestinaltrakt, mit maximalen Plasmaspiegeln nach rund zwei Stunden. Der Wirkstoff verteilt sich gut im Gewebe und weist eine hohe Plasmaproteinbindung auf. Seine lange Halbwertszeit erlaubt eine verlängerte Wirkphase. Der Metabolismus erfolgt über das hepatische Enzymsystem CYP3A4, mit der Bildung inaktiver Metaboliten. Exkretion geschieht primär über den Stuhl. Die Häufigkeit von Nebenwirkungen steigt mit der Dosis, wobei vor allem vasodilatatorische Effekte dominieren. Ein gängiger Bezugspunkt in pharmakologischen Analysen ist cialis ohne rezept, das mit dieser Wirkstoffklasse assoziiert ist.

C:\ncs-vp8\221-3-inhalt.vp

Zeitschrift für Kristallographie
New Crystal Structures
Volume 221 · Issue 3 · 2006
Inorganic Crystal Structures
S. Stoyko, S. Oryshchyn, V. Babizhetskyy and R. Guérin Crystal structure of yttrium nickel phosphide, J.-P. Wang, P.-T. Ma and J.-Y. Niu Y20Ni42P30.34 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 259 Re-investigation of the crystal structure of dodecasodium O. Sichevych, R. Cardoso-Gil and Yu. Grin Na12[Mn(Nb6O19)2] · 52H2O . . . . . . . . . . . . . . . . . . . . . . . . 235 Refinement of the crystal structure of europium digallide, EuGa2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 261 S. Budnyk, Yu. Prots, Yu. B. Kuz’ma and Yu. Grin Crystal structures of trigadolinium tetraphosphidohepta- O. Sichevych, Yu. Prots, W. Schnelle, M. Schmidt and 3Pd7P4, and triterbium tetraphosphidohepta- Crystal structure of dieuropium trigallium iridium, 3Pd7P4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 238 Eu2Ga3Ir . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 263 A. Jiménez, J. D. Rodríguez, L. Torre-Fernández,M. Prieto and S. García-Granda O. Sichevych, Yu. Prots and Yu. Grin Crystal structure of dicalcium sodium monohydrogen Re-investigation of the crystal structure of trieuropium octagallide, Eu3–xGa8+3x (x = 0.12) . . . . . . . . . . . . . . . . . . . 265 E. Dashjav, W. Schnelle, F. R. Wagner, G. Kreiner and Crystal structure of bismuth triiodate dihydrate, Crystal structure of praseodymium dimolybdenum Bi[IO3]3 · 2H2O . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 243 disilicide carbide, PrMo2Si2C . . . . . . . . . . . . . . . . . . . . . . . 267 D. Grüner, A. Ormeci and G. Kreiner Crystal structure of ytterbium triiodate dihydrate, Crystal structure of niobium chromium nickel, Yb[IO3]3 · 2H2O. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 245 Nb(Cr1–xNix)2 (x = 0.49) . . . . . . . . . . . . . . . . . . . . . . . . . 269 Crystal structure of indium triiodate dihydrate, Crystal structure of distrontium oxide diiodide, Sr2OI2. . . . 271 In[IO3]3 · 2H2O . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247 Organic and Metalorganic Crystal Structures
Crystal structure of indium triiodate trihydrate, In[IO3]3 · 3H2O . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 249 D.-Y. Wei, S.-J. Huang, J. Sun and Y.-Q. Zheng Crystal structure of diaquadidysprosium triglutarate P. W. Menezes, S. Hoffmann, Yu. Prots and R. Kniep tetrahydrate, Dy2(H2O)2[O2C(CH2)3CO2]3 · 4H2O . . . . . . . 273 I. Warad, S. Al-Resayes and K. Eichele Crystal structure of trans-dichloro-1,3-propanediamine- 2O8(OH)]. . . . . . . . . . . . . . . . . . . 251 bis[(2-methoxyethyl)diphenylphosphine]ruthenium(II), P. W. Menezes, S. Hoffmann, Yu. Prots and R. Kniep RuCl2(C3H10N2)(C15H17OP)2 . . . . . . . . . . . . . . . . . . . . . . . 275 S. Sörgel, I. Brüdgam, H. Hartl and H.-U. Reißig Crystal structure of 2-bromo-1,4,5,7,8-pentamethoxy- monophosphate), RbSc[BP2O8(OH)]. . . . . . . . . . . . . . . . . . 253 naphthalene, C10H2Br(OCH3)5 . . . . . . . . . . . . . . . . . . . . . . 278 A. Leithe-Jasper, R. Cardoso-Gil, R. Ramlau and L. Yang, W. Yu, T. Wu, T.-L. Zhang, J.-G. Zhang, Crystal structure of tetraytterbium septarhodium Crystal structure of carbohydrazidium(1+) p-toluene- hexaantimony, Yb4Rh7Sb6 . . . . . . . . . . . . . . . . . . . . . . . . . . 255 sulfonate, (NH2NHCONHNH3)[CH3C6H4SO3] . . . . . . . . . 281 F. Haarmann, Yu. Prots, S. Göbel and H. G. von Crystal structure of (2,6-diisopropyl-phenyl)[N- Crystal structure of tristrontium octagallide, tris(pentafluorophenyl)-boronyl-pyridin-2-yl]amine, Sr3–xGa8+3x (x = 0.15). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 257 (C6F5)3B(C5H4N)(C12H18N) . . . . . . . . . . . . . . . . . . . . . . . . 283 Crystal structure of (1,8-diethyl-1,3,4,9-tetra- Crystal structure of tetrakis(melaminium) 1,2,4,5- hydropyrano[3,4-b]indol-1-yl)acetic acid (2-hydroxy-benzylidene)hydrazide, C24H27N3O3 . . . . . . . . 285 (C3H7N6)4[C6H2(COO)4] · 8H2O. . . . . . . . . . . . . . . . . . . . . 313 Q. Deng, W.-J. Jiang, Z.-S. Peng, Y.-F. Long and T.-J. Cai Y.-H. Deng, Y.-L. Yang and X.-J. Yang Crystal structure of aquabis(acrylato-O,O¢)- Crystal structure of diiodo-bis[(4R,5R)-trans-4,5- (1,10-phenanthroline-N,N¢)zinc(II) hydrate, bis[(diphenylphosphinomethyl)-2,2-dimethyl-1,3- Zn(C3H3O2)2(H2O)(C12H10N2) · H2O . . . . . . . . . . . . . . . . . 287 dioxalane]dicopper(I), Cu2I2(C31H32O2P2)2 . . . . . . . . . . . . 316 R. D. Ernst, R. Basta and A. M. Arif L. Yu, P.-T. Ma, J. Li and J.-P. Wang Refinement of the crystal structure of bis(2-hydroxy- cyclohexadienyl)vanadium, V(C8H11)2 . . . . . . . . . . . . . . . . 289 1,10-phenanthroline)dicopper(I), Cu2(C12H7N2O)2. . . . . . . 319 R. D. Ernst, B. G. Harvey and A. M. Arif Crystal structure of (hydrido)(h3-butenyl)- bis(h5-pentamethylcyclopentadienyl)zirconium, trimethylspiro[2H-1-benzopyran-2,2¢-indoline], 4H7)[C5(CH3)5]2(H) . . . . . . . . . . . . . . . . . . . . . . . . . . . 291 C19H17BrClNO. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321 R. D. Ernst, V. Kulsomphob and A. M. Arif Crystal structure of (h5-2,4-dimethylpentadienyl)[h2-rel- M.-H. Wu, X.-H. Yang, W.-D. Zou, W.-J. Liu and C. Li (aR)-a-[[(1R,5E)-5-[(1,1-dimethylethyl)imino]-1,3- Refinement of the crystal structure of (E)-1,3- dimethyl-2-cyclopenten-1-yl]methyl]-N-(1-methylethyl)- diphenyl-2-propen-1-one, C15H12O . . . . . . . . . . . . . . . . . . . 323 benzenemethanaminato-kN][2-(isocyano-kC)-2-methyl- Crystal structure of bis(cyclopropyl-4-bromosalicyl- aldiminato)cobalt(II), Co(C20H18BrNO)2 . . . . . . . . . . . . . . 325 Crystal structure of bis(N-(2-aminoethyl)salicyl- Y.-H. Luo, X.-J. Hu, J.-K. Liu, H. Zhang, Y. Li, [Fe(C9H11N2O)2][NCS] . . . . . . . . . . . . . . . . . . . . . . . . . . . . 296 H.-J. Yang and R.-J. WangCrystal structure of 5,11,17,23-tetrabromo-25,27- M.-Q. Cheng, L.-F. Ma and L.-Y. Wang Crystal structure of catena-[(1,10-phenanthroline-N,N¢)- C30H24Br4O4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 327 bis(m-acetato-O,O¢)lead(II)], Pb(C12H8N2)(CH3COO)2 . . . 299 X.-J. Hu, H.-J. Yang, J.-K. Liu, H. Zhang, Y. Li, G. Steiner, K. Wurst, B. Bildstein and H. Kopacka Y.-H. Luo, Y.-H. Luo and R.-J. Wang Crystal structure of dichlorobis[N-(2,6-diisopropyl- Crystal structure of 5,17-bis(N-tert-butylhydroxy- phenyl)benzimidimidazolide]palladium(II), amine)-25,26,27,28-tetrapropoxycalix[4]arene, PdCl2(C22H25N3)2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 301 C48H66N2O6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 329 G. Steiner, K. Wurst, B. Bildstein and H. Kopacka Q.-H. Jin, J.-C. Dong, H.-W. Gao, X.-L. Xin, L. Yang Crystal structure of dichloro(3-cyclopentadienyl- 3-methyl-1-phenyl-butyliden-2,6-dimethylphenyl- Crystal structure of catena-poly[(m-2-aminopyrimidine- amino)chromium(III), CrCl2(C24H26N) . . . . . . . . . . . . . . . . 303 N,N¢)bis(m-chloro)bis(triphenylphosphine)dicopper(I)], M. Zareef, R. Iqbal, G. Qadeer, W.-Y. Wong, H. Akhtar 2Cl2[P(C6H5)3]2(C4H5N3) . . . . . . . . . . . . . . . . . . . . . . . . 332 Z.-S. Peng, W.-J. Jiang, Q. Deng, Y.-F. Long and T.-J. Cai Crystal structure of 2-bromobenzoic acid hydrazide, Refinement of the crystal structure of catena-[(1,10- C7H7BrN2O . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 305 phenanthroline-N,N¢)-(m3-molybdato(VI))copper(II)] M. Zareef, R. Iqbal, J. H. Zaidi, G. Qadeer, W.-Y. Wong monohydrate, Cu(C2H10N2)(MoO4) · H2O . . . . . . . . . . . . . 335 Crystal structure of picolinic acid hydrazide, C D. B. Werz, S. Balalaie, F. Rominger and Z. Oloumi Crystal structure of 2-(2-propynyloxy)benzaldehyde, P. Lemoine, A. Bekaert, J. D. Brion and B. Viossat C10H8O2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 337 Crystal structure of hexakis(m2-acetato)tris(acetonitrile- D. B. Werz, S. Balalaie, F. Rominger and Z. Oloumi 3-oxo-trialuminum(III) tetrachloroaluminate, Crystal structure of 2-[6-(2-formylphenoxy)-2,4- 3(C2H3O2)6(C2H3N)3O][AlCl4] . . . . . . . . . . . . . . . . . . . 309 hexadiynyloxy]benzaldehyde, C20H14O4 . . . . . . . . . . . . . . . 339 J. Zukerman-Schpector, R. Oliveira da Silva, P. R. Olivato,E. Vinhato, A. Rodrigues and C. R. Cerqueira Jr. Crystal structure of 2-phenylsulfinyl-cyclohexanone, Crystal structure of 2¢-hydroxyacetophenone nicotinoyl- C12H14O2S . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 311 hydrazone monohydrate, C14H15N3O3 · H2O. . . . . . . . . . . . 341 J.-N. Feng, Y.-Z. Zhou, H.-J. Zhu and S.-J. Tu Crystal structure of ethanolammonium dioxo-(N-(2- Crystal structure of tetraaqua-bis(norfloxacin)barium(II) ethanolato)-2-oxy-3-methoxybenzaldiminato-O,N,O¢)- [Ba(H2O)4(C16H17FN3O3)2][C6H4(COO)2] · H2O. . . . . . . . 372 (NH3CH2CH2OH)[VO2{(C6H4(OCH3)(O)CHNCCH2CH2O}]. . . 343 W.-D. Wang, H. Wang, W.-J. Feng, Z.-M. Jin and M.-L. Hu G. N. Kaluderovic, G. A. Bogdanovic and T. J. Sabo Crystal structure of caffeinium perchlorate monohydrate, Crystal structure of ethylenediammonium-N,N¢- (C8H11N4O2)[ClO4] · H2O . . . . . . . . . . . . . . . . . . . . . . . . . . 375 di-3-propionic acid tetrachloroplatinate(II),(CH2NH2(CH2)2COOH)2[PtCl4] . . . . . . . . . . . . . . . . . . . . . 345 Crystal structure of (acetonitrile-N)copper(I) cyanide, [Cu(CH3CN)][CN] . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 377 Crystal structure of rel-(3aR,4S,6aS)-4-chloromethyl-6-methyl-3,6a-diphenyl-3a,4,6,6a-tetrahydro-isoxazolo- Crystal structure of dicyano(N-(1-iminoethyl)- 18H17ClN2O2 . . . . . . . . . . . . . . . . . . . . . 347 acetamidine)palladium(II), Pd(CN)2(C4H9N3). . . . . . . . . . . 379 W. Frey, S. Shiva and V. JägerCrystal structure of rel-(3aR,6aS)-6-methyl-3,6a-di- G. Le Bras, A. Bekaert, B. Viossat, J.-F. Peyrat, M. Alami, phenyl-3a,4,6,6a-tetrahydro-isoxazolo[5,4-c]isoxazole, 17H16N2O2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 349 H.-M. Guo, B.-S. Zhang and Y.-H. Wang Q.-H. Jin, L. Yang, X.-L. Xin, H.-W. Gao, J.-C. Dong and Crystal structure of bis(1,10-phenanthroline-N,N¢)bis(2- Crystal structure of aqua(phenanthroline-N,N¢)- (glycinato-N,O)copper(II) bromide hydrate, 7H4O2Cl)2(C12H8N2)2] · 2.5H2O . . . . . . . . . . . . . . . . 352 [Cu(NH2CH2COO)(C12H8N2)(H2O)]Br · H2O . . . . . . . . . . 383 B.-S. ZhangCrystal structure of (2,2¢-bipyridine-N,N¢)bis(2- aquabis(2,2¢-bipyridine)bis(terephtalato)dicopper(II), C. A. De Simone, V. L. M. Guarda, S. L. Galdino and Cu2(H2O)(C10H8N2)2(C8H4O4)2 . . . . . . . . . . . . . . . . . . . . . 385 Crystal structure of 4-butyl-6-nitro-2H-1,4-benzothiazin- Crystal structure of bis[(1,3-bis(4-pyridinium)- 3-one, C12H14N2O3S . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 357 propane)][ß-hexacosaoxooctamolybdate(VI)], C. R. Doyle, M. D. Zimmerman, M. Chruszcz, 13H16N2)2[Mo8O26] . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 388 M. Cymborowski, A. Gawlicka-Chruszcz and W. Minor P.-G. Li, Q.-L. Wang, D.-S. Li, F. Fu and G.-C. Qi Crystal structure of 6-(4-difluoromethoxy-3-methoxy- Crystal structure of bis(1,10-phenanthroline-N,N¢)silver(I) phenyl)-3(2H)-pyridazinone, C12H10F2N2O3. . . . . . . . . . . . 359 mononitrate, [Ag(C12H8N2)2][NO3]. . . . . . . . . . . . . . . . . . . 391 S. Guo, R. Hauptmann, C. Beyer, T. Kollmann and Refinement of the crystal structure of sinoacutine, C19H21NO4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 361 Crystal structure of pentamethylpyrylium triiodide, [(CH3)5C5O][I3] . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 393 I.-C. Hwang and K. HaCrystal structure of aquachloro[N,N¢-bis(3-ethoxy- F.-Q. Cao, Y. Wang, N. Okabe and M. Odoko salicylidene)ethylenediiminato]manganese(III) dihydrate, Crystal structure of aquabis(4-aminobenzoato)cadmium [Mn(C20H22N2O4)Cl(H2O)] · 2H2O . . . . . . . . . . . . . . . . . . 363 dihydrate, Cd(H2O)(NH2C6H4COO)2 · 2H2O . . . . . . . . . . . 395 S. Florio, V. Capriati, R. Luisi, A. Salomone and C. Cuocci Crystal structure of aquachloro[N,N¢-bis(3-ethoxy- Crystal structure of (N-tert-butyl-3,4-diphenyl-1,2- salicylidene)propylenediiminato]manganese(III) dihydrate, oxazetidin-4-yl)methanol, C19H23NO2. . . . . . . . . . . . . . . . . 398 [Mn(C21H24N2O4)Cl(H2O)] · 2H2O . . . . . . . . . . . . . . . . . . 365 Y. B. Lee, T. H. Kim, I.-C. Hwang and K. Ha Crystal structure of tetra(2-aminopyrimidine)di- Crystal structure of N-benzoyl-4,4-dimethyl-2-methyl- amino-2-thiazoline, C13H16N2OS. . . . . . . . . . . . . . . . . . . . . 367 [Co2(CH3O)2(C4H5N3)4][ClO4]2 . . . . . . . . . . . . . . . . . . . . . 401 M.-Q. Cheng, L.-F. Ma and L.-Y. Wang Crystal structure of (phenanthroline-N,N¢)-N-carbamoyl- Crystal structure of tetra(2-aminopyrimidine)di- methyliminodiacetato-copper(II) dihydrate, methanolato-dinickel(II) di(tetrafluoroborate), [Cu(C6H8N2)(C12H8N2)] · 2H2O . . . . . . . . . . . . . . . . . . . . . 369 [Ni2(CH3O)2(C4H5N3)4][BF4]2 . . . . . . . . . . . . . . . . . . . . . . 403 T.-J. Cai, W.-J. Jiang, Z.-S. Peng, Y.-F. Long and Q. Deng Crystal structure of bis(1,3-diaminepropane)carbonato- Crystal structure of aquabis(acrylato-O,O¢)(1,10- phenanthroline-N,N¢)cadmium(II), [Mn(C3H10N2)2(CO3)]Cl · H2O . . . . . . . . . . . . . . . . . . . . . . 405 Cd(H2O)(C3H3O2)2(C12H10N2) . . . . . . . . . . . . . . . . . . . . . . 421 Crystal structure of m-terephthalatobis[bis(1,3-diamino- Crystal structure of dichloro-bis(n-pentyl)tin(IV), Sn(C5H11)2Cl2, tin-halide compounds – part VI . . . . . . . . . 423 [Mn2{C3H6(NH2)2}4{C6H4(COO)2}][ClO4]2 . . . . . . . . . . . 407 S.-P. Xu, C.-H. Liu and S.-F. Wang Crystal structure of acetato-m-N,N¢-bis(salicylidene)- 3-methyl-3-aza-1,5-pentanediaminocobalt(III), Co(C2H3O2)(C21H25N3O2). . . . . . . . . . . . . . . . . . . . . . . . . . 409 H. Maisel, G. Glatz, T. Irrgang and R. Kempe Crystal structure of dicyclohexyl-2,2¢-dipyridylamido- Instructions to Contributors
phosphane, C22H30N3P. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 411 T. Irrgang, A. Spannenberg and R. Kempe Crystal structure of bis(1,3-bis[{4-methyl-pyridin-2-yl}- amido]-1,1,3,3-tetramethyldisiloxane)dichromium dichloride, [(C16H24N4OSi2)CrCl]2 . . . . . . . . . . . . . . . . . . . 413 Further details of the structure determination can be accessed at Crystal structure of tetrakis[(4-methyl-pyridin-2-yl)tri- Data with CSD numbers can be obtained from the Fachinforma- methylsilanyl-amido]zirconium(IV), Zr(C9H15N2Si)4. . . . . 415 tionszentrum Karlsruhe, Gesellschaft für wissenschaftlich-tech- nische Information mbH, D-76344 Eggenstein-Leopoldshafen, Z. García-Hernández, B. Wrackmeyer, M. Herberhold, Germany (e-mail: docdel@fiz-karlsruhe.de).
Data with CCDC numbers can be obtained from the Cambridge Crystal structure of 3,4,7,8-bis(1,2-dicarba-closo- Crystallographic Data Centre (CCDC), 12 Union Road, dodecaborano[1,2])-1,2,5,6-tetraselenacyclooctane Cambridge CB2 1EZ, UK, (fax: +44-(0)1223-33 60 33 or e-mail: benzene solvate, [(C2B10H10)Se2]2 · C6D6 . . . . . . . . . . . . . . 419

Source: http://jxzx.bucea.edu.cn/Download/16825.pdf