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Antibody to Progesterone Receptor
Cat. No. VP-P974
Product Specifications
Progesterone Receptor mouse monoclonal antibody
Immunoglobulin class:
Synthetic peptide of human progesterone receptor.
Western blotting:
Lyophilized tissue culture supernatant containing 15mM sodium azide. Reconstitute with 2 ml of distilled water.
MCF-7 cell lystate shows bands at 87kD and 110 kD.
Species cross-reactivity:
* Recommended dilutions using VECTASTAIN® Elite® Storage Conditions:
Keep unopened vial at 2 - 8 °C for 1 year. Onceopened it is recommended that the stock solution be Functional Aspects:
aliquoted and quick frozen and stored at -20 °C. Do Progesterone receptor (PR) is expressed in a variety of different tissues but is found most prominently in thefemale reproductive tract. A large amount of researchhas focused on the differential expression of PR inhuman breast and uterine cancers. This antibody willhelp detect the presence of PR in tissues and cell lines.
Selected References
Leake R, Barnes D, Pinder S, et al. Immunohistochemical detection of steroid receptors in breast cancer: a working protocol. Journal of Clinical
Pathology. 53 (8): 634-635 (2000).
Clark G M and McGuire W L. The clinical usefulness of oestrogen-receptor and other markers of hormone dependence. Proceedings of the Royal
Society of Edinburgh. 95B: 145-150 (1989).
Giri D D, Goepel J R, Rogers K, et al. Immunohistological demonstration of progesterone receptor in breast carcinomas: correlation with radioligand
binding assays and oestrogen receptor immunohistology. Journal of Clinical Pathology. 41: 444-447 (1988).
Raemakers J, Beex L, Pieters G, et al. Progesterone receptor activity and the response to first endocrine therapy. European Journal of Cancer and
Clinical Oncology. 23(4): 443-447 (1987).
Gross G, Clark G, Chamness G, et al. Multiple progesterone receptor assays in cancer of the breast. Cancer Research. 44: 837-840 (1984).
Clark G M, McGuire W L, Hubay C A, et al. Progesterone receptors as a prognostic factor in stage II breast cancer. The New England Journal of
Medicine. 309(22): 1343-1347 (1983).
Mason B H, Holdaway I M, Mullins P R, et al. Progesterone and oestrogen receptors as prognostic variables in breast cancer. Cancer Research.
43: 2985-2990 (1983).
Stewart J, King R, Hayward J, et al. Oestrogen and progesterone receptors: correlation of response rates, sites and timing of analysis. Breast
Cancer Research and Treatment. 2: 243-251 (1982).
Stefanini M, De Martino C and Zamboni L. Fixation of ejaculated spermatozoa for electron microscopy. Nature. 216: 173-174 (1967).
VP-P974 is recommended FOR PROFESSIONAL AND RESEARCH USE ONLY Vector Laboratories, Inc., 30 Ingold Road, Burlingame, CA 94010 U.S.A.
Tel: (650)697-3600 • Fax (650)697-0339 • Email: vector@vectorlabs.com • Website: www.vectorlabs.com

Source: http://www.vectorlabs.com/data/protocols/VPP974.pdf


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Nagoya University Graduate School of Medicine Education: Bachelor of Engineering, Dept. of Transportation Engineering, Tokyo Univ. of Sci., Master of Engineering, Dept. of Civil Engineering, Tokyo Univ. of Sci., 1993 Degree: Doctor of Engineering, Tokyo Univ. of Sci., 1999, Title of the Thesis: Design and analysis of randomized clinical trials with recurrent events. Employment: 1993.4-1995.

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