(E-News Letter) Drug Information & Pharmacovigilance Centre, Tamil Nadu Pharmacy Council, Tele fax: 91 - 044 - 2473 0061, e -mail: Web site: http://tnpc.ac.in Contact: 91 44 -24338421 Antidepressants as Treatment Immediately after Stroke? IN SIGHT
Research suggests a new strategy for the
treatment of stroke. Research in rodents
• Antidepressants as Treatment Immediately after Stroke?
known as neurogenesis, lessens the severity
function following a stroke. The research
• List Of Approved Drug
neurogenesis in rodents could have benefits
From 01.01.2010 To 28.2.2010
suitable for study in human clinical trials.
Results of the research appear the week of
"What this study shows more convincingly
than in the past is that the production of new
involve screening any of the existing drugs
neurons after stroke is beneficial in rodents,"
that support neurogenesis, compared stroke
said Buck faculty member. "Assuming that
neurogenesis is also beneficial in humans,
genetically altered and treated to either grow
or not grow new neurons prior to stroke.
purposes and already shown to promote new
percent larger in the animals that did not
studying as a potential treatment for stroke
grow new neurons; the rodents that did grow
in humans. For example, antidepressants are
often used to treat post-stroke depression,
in motor function following the stroke. The
but their potential for improving outcome
exact mechanism by which the new neurons
Previous research by the same group at the
Although the possibility of using existing
drugs for the treatment of stroke is one that
attempts to heal itself following stroke by
may excite patients and patient advocates,
growing new neurons, but it has not been
those suffering from stroke should not treat
themselves, even with FDA-approved drugs,
without medical advice. "Everything has
each year. Stroke is the third leading cause
antidepressant carries the possibility of
of death in the U.S. and is the leading cause
making someone worse. These drugs need to
be tested in a controlled clinical setting."
country. Treatments for stroke are limited.
Clot busting drugs, which have to be given
within hours of the stroke, have been of
great benefit to a small number of patients,
but stroke is not usually diagnosed in time
When taken with methotrexate, a new pill
including interleukin-6 and matrix metalloproteinase-3 (mmp-3) levels
arthritis drug. There was not a significant
(fostamatinib disodium) is part of a new
class of rheumatoid arthritis drugs that
blocks syk kinase, which can trigger the
injection or infusion, this new rheumatoid
arthritis drug is taken by mouth, which is
lymphoma, lupus and type I diabetes.
College of Medicine, in Rochester, Minn.
drug methotrexate, those participants who
effect and it is kind of exciting that they
the new syk kinase inhibitor twice a day
are oral,” he says. If the new findings are
act differently. “Together with biologics,
LIST OF APPROVED DRUG FROM 01.01.2010 TO 28.2.2010 PRODUCT NAME INDICATION APPROVAL
Ferrous ascorbate 100mg + Folic For iron, folic acid & omega-3-fatty
acid 1.1 mg tablet and Omega-3- acid deficiency
Sphaeranthus Indicus Extract For the management of psoriasis.
conjunctivitis and urticaria) and for prevention and treatment of motion sickness
advanced or metastatic Non Smal Cel Lung Cancer (NSCLC) other than predominantly squamous cel
histology in patients whose disease has not progressed immediately following platinum-based chemotherapy. First line treatment should be a platinum doublet with gemcitabine, paclitaxel or docetaxel. 16-Jan-10
Levobetaxolol HCl Opthalmic pressure in patients with chronic
open-angle glaucoma or occular hypertension.
Sarpogrelate Hydrochloride film symptoms including ulcer,
associated with chronic arterial occlusion.
associated with acute upper respiratory tract inflammation, acute musculoskeletal disorders, pain after operative intervetion and
following trauma, chronic condition like rheumatoid arthritis, osteoarthritis etc for short term management of acute painful episodes.
tocopherol 163-225mg + glycerol (anhydrous) 25gm + Egg lecithin
12gm + sodium hydroxide (to approx pH 8) + sodium pleate 0.3mg emulsion for infusion in 100ml.
retroviral agents for the treatment of human immunodeficiency virus
experienced patients with evidence of HIV-1 replication despite ongoing retroviral therapy.
Pregabalin SR Tablet 75mg (Additional Strength)
Rivaroxaban film coated Tablets thromboembolism in patients (VTE)
in adult patients undergoing hip or knee replacement surgery.
Gel 14mg/ml, 18mg/ml, 25.5mg/ml (Additional Strength)
staple lines in lung resection procedures. (2)Patients undergoing cardiac surgery to prevent or reduce the incidence, severity and extend of post surgical adhesion formation.
(3)Patients undergoing laparotomy or laproscopic abdomino-pelvic surgery as an adjunct to good surgical technique intended to reduce the incidence, severity and extent of post surgical adhesion formation.
chronic stable angina pectoris in coronary artery disease patients with normal sinus rhythm, indicated
in combination with beta-blockers in patients inadequately controlled with an optimal beta-blocker dose and whose heart rate is >60bpm.
anticancer drugs is indicated for remission induction in acute non-lymphocytic leukemia of adults and children. It has also been found useful in the treatment of acute
lymphocytic leukemia and the blast phase of chronic myelocytic leukemia. Intrathecal administration of cytarabine is indicated in the prophylaxis and treatment of meningal leukemia.
Olopatadine Hcl Nasal Spray 0.6% seasonal al ergic rhinitis in patients 6 w/w (Additional Indication)
acetate trihydrate 3.27gm + L-malic acid 0.67gm in 1000ml solution for infusion
Chemical y Modified Sodium surgery for reducing the incidence,
extent and severity of postoperative 11-Feb-10
Thiocolchicoside 4mg/8mg tablets acute painful musculoskeletal
with upper & lower respiratory tract
infections, skin and soft tissue infections
pediatric patients using this medication. Warning on severe liver injury with propylthiouracil
hyperthyroidism it may be appropriate to
reserve use of propylthiouracil for those
Warning to the label for propylthiouracil,
who cannot tolerate other treatments such
information about reports of severe liver
occurrence of birth defects that have been
treatment of choice during and just before
patients who cannot tolerate methimazole
Propylthiouracil may be the treatment of
propylthiouracil as well as meetings with
methimazole use during the first trimester
use in pediatric patients, except in rare
Healthcare professionals should be aware
of this new safety information in the drug
outlined above. Patients should carefully
read the Medication Guide each time they
get their prescription so they are aware of
the risks and benefits of this medication. Information for Healthcare Professionals
acute liver failure, including fatal cases,
have been reported in adult and pediatric
dose inhalers (MDI) used to treat asthma
international agreement to ban substances
that deplete the Earth’s ozone layer. The
the inhaler and into the lungs of patients.
Asthma and COPD Inhalers That
The decision to phase out the products is
Contain Ozone-depleting CFCs to be
the latest in a series of decisions related
from the market as required by the Clean
the ozone layer miles above the Earth that
out the seven remaining products in 2007
eliminated the production of CFCs in the
United States as of Jan. 1, 1996, except
for certain limited uses, such as MDIs. The affected products and their phase out schedule include Inhaler Medication Last Date to be Manufacturer manufactured, sold or dispensed in U.S.
Aerosol (triamcinolone)Intal Inhaler (cromolyn)
ipratropium in combination)Maxair Autohaler
removal of all or a part of the pancreas
FDA has approved three PEPs. What What are pancreatic enzyme products happens to the unapproved PEPs? (PEPs)? How are they used?
pancrelipase, a mixture of the digestive
available to patients because they do not
effectiveness, and product quality. In the
improve food digestion in patients whose
had four years to obtain FDA approval of
pancreatic enzymes because of conditions
preparing and submitting applications for
their treatment will be safe, effective, and
What are the key points patients need to know about PEPs?
approved PEPs sold in the United States.
professional to make sure they have a plan
weeks to adjust the dose of the new PEP.
with each prescription of an FDA-approved
PEP. The Medication Guide is written for
additional PEPs even after the April 28,
professional about any concerns they have
approved PEP. This will help ensure that
conducting tests to evaluate the feasibility
data-driven recommendations are available
to guide the use for all patients requiring
interchangeable at the pharmacy. Patients
standards for safety, effectiveness, and
weeks for a patient to adjust their dose of
the new PEP. Individual patient response
an unapproved PEP to an approved one.
that PEPs should only be taken as directed.
for administration via gastrostomy tubes, a
small number of patients may require PEPs
Möglichkeiten der Parkinson-Frühdiagnostik und wesentliche Therapiesäulen Vortrag am 4.07. 2008 in Stuttgart, Prof. Dr. Daniela Berg, Universität Tübingen 1. Frühzeichen der Parkinsonerkrankung Die Parkinsonkrankheit wird durch die Symptome Akinese (Bewegungsverarmung), Rigor (erhöhter Muskeltonus), Ruhezittern und Posturale Instabilität (Störung der Stand- und Gangsicherhe
http://www.aocs.org/member/division/news/issues/040108photx. AOCS Phospholipid Division Newsletter April 2008As you are all aware, the AOCS Annual Meeting is fast approaching. Along with theopportunity to network and renew acquaintances comes the opportunity for continuingpersonal and professional education. Also it is a wonderful opportunity to get involvedand help promote the organizations tha