PREPARATION Discuss with woman Time and mode of delivery Woman diet-controlled with normally grown fetus:
advise induction of labour at 40 weeks’ gestation
advise induction of labour at 38 weeks’ gestation Analgesia and anaesthesia Offer women with diabetes and co-morbidities (e.g. obesity or autonomic neuropathy)
obstetric anaesthetic assessment in third trimester
Care during and after labour Analgesia and anaesthesia
Prevention of neonatal hypoglycaemia
Care of baby/breastfeeding PRETERM LABOUR Pulmonary maturation delayed in fetuses of diabetic women, particularly where control
Where premature delivery anticipated, give betamethasone for women with established
diabetes – see Preterm labour guideline
Steroid administration worsens diabetic control and may lead to ketoacidosis in women
with pre-existing type 1 diabetes – anticipate an increase in insulin requirement and administer insulin as per local Trust policy for steroids in diabetic pregnancy
INDUCTION OF LABOUR
See Induction of labour guideline Diabetic control Before labour established, normal metformin/insulin regimen and diet DURING LABOUR Risk Increased risk of shoulder dystocia particularly if baby macrosomic – ensure obstetric
registrar is available on delivery suite during second stage – see Shoulder dystocia guideline
Increased risk of cephalopelvic disproportion – be vigilant for delay and, if occurring, use
Monitoring during labour Woman Record capillary glucose level hourly
Once sliding scale regimeN commenced, monitor blood glucose hourly
Monitor blood glucose at 30 min intervals after induction of general anaesthesia and birth
Check urine for ketones Continuous fetal monitoring Maternal hyperglycaemia may cause fetal acidosis, check maternal glucose if any EFN
Fetal blood sampling if indicated as normal labour – see Fetal blood sampling guideline Metformin and diet controlled If blood glucose elevated e.g. persistently above Unit threshold, commence insulin and IV
fluid regimen below
Gestational diabetes mellitus Insulin controlled – Dependent on amount of insulin required – dosage as per local
Elective caesarean section If caesarean section carried out before 39 weeks’ gestation, consider administration of
antenatal steroids. This will require sliding scale
If not on sliding scale for steroids, give usual metformin/insulin day before procedure
Commence insulin and fluid regimen from 0600 hr. See below Emergency caesarean section Check blood glucose level and commence insulin and IV fluid below INSULIN AND IV FLUID REGIMEN 500 mL glucose 10% with 10 mmol potassium chloride 8-hrly
50 units soluble insulin (Actrapid/Humulin S) in 50 mL sodium chloride 0.9% via syringe
pump according to blood glucose checked at time of admission and hourly thereafter by glucometer
Determine rate of fluid infusion depending on blood glucose concentration and local policy
Aim to keep woman’s blood glucose concentration between 4–9 mmol/L
Most women will need 2–4 units/hour
Avoid large changes in insulin infusion rate and therefore in glucose concentration
If blood glucose not maintained within normal range, contact diabetes team
Always use commercially produced pre-mixed bags of glucose 10% with potassium
POSTNATAL MANAGEMENT Diabetes team will write management plan Inform women with insulin-treated diabetes that they are at increased risk of hypoglycaemia in postnatal period, especially when breastfeeding. Advise to have a meal or snack available before or during feeds
Stopping insulin and fluid regimen Continue sliding scale regimen until able to eat and drink normally Type 1 diabetes Revert to pre-pregnancy reduced insulin requirements or the regimen advised by diabetes
Keep sliding scale running for 30–60 min after first subcutaneous insulin dosage
May require less insulin if planning to breastfeed
Review by diabetes team as appropriate Type 2 diabetes Stop insulin and fluid regimen
Metformin not contraindicated in breastfeeding, but avoid sulphonylureas
Gestational diabetes Women with gestational diabetes mellitus who have required sliding scale will cease to
Arrange postnatal OGTT or fasting blood glucose at 6 weeks Neonatal care See Staffordshire, Shropshire & Black Country Newborn Network Hypoglycaemia
Future plans While still using contraceptives, mother to discuss future pregnancy with diabetes team
who will provide information on pre-conception care
Long-term safety assessment of a cohort of post-menopausal women treated with Anastrozole as adjuvant treatment for hormone-dependent breast cancer. Baseline data T. Delozier, EC. Antoine, A. Fontana, JP. Guastalla, C. Roux, L. Mauriac, Eric Vicaut, CLCC F. Baclesse, Caen ; Clinique Hartmann, Neuilly ; Hôpital E. Herriot, Lyon ; CLCC L. Bérard, Lyon ; Hôpital Cochin, Paris ; Institut
República de Honduras – Ley de Cooperativas de Honduras – Decreto No. 65-87 DECRETO NÚMERO 65-87 EL CONGRESO NACIONAL, CONSIDERANDO: Que el cooperativismo racionaliza el uso de la cooperación humana comomedio para obtener el bienestar material y la satisfacción espiritual del hombre. CONSIDERANDO: Que el cooperativismo es un sistema económico social eficaz para eldesarrollo económi