1995-2000 Group leader at the Genzentrum of the
since Nov. 2000 Professor of Biochemistry at the
Karolinska Institute Stockholm, Sweden.
Work in the lab of Prof. Dr. Alexander von
Institute of Crystallography, Free University
repressor-tet operator interactions in the
Genzentrum, Ludwig-Maximilians-Universität, Munich,
1993, awarded by the "Vereinigung für
1982-1987 Student of Biology, FA University
1988-1992 Doctoral thesis: "Molecular mechanisms of
the regulation of tetracycline resistance
Prof. Dr. rer. nat. Ralf Heinrich Baumeister
determinants", major supervisor: Prof. Dr.
1992-1995 Postdoctoral research fellow in the lab of
Phone: +49-(89) 5996-458, Fax: +49-(89) 5996-415
gene unc-86 for the specification and dif-
Internet:http://www.lmb.uni-muenchen.de/groups/bmeis-
ferentiation of the C.elegans nervous sys-
GENE TECHNOLOGY FORUM 2001 TARTU, ESTONIA
C.elegans, an Animal Model for the
The different genome projects have resulted in an expo-
nential increase in sequence information available in the
databases. At the same time, the number of functionally
characterized genes is only increasing linearly. How can
we increase the speed of functional genomics to make
full use of the data mining? Model organisms have
helped significantly to understand the roles of particular
genes in an organism. The classical approaches to
address gene function first involves the inactivation of a
given gene and the monitoring of the resulting conse-
quences. For single factors, this method was success-
fully used in the model organisms Drosophila
melanogaster and mouse. However, in order to upscale
this knock-out methodology and subsequent analysis,
these models have a significant disadvantage: the time
and effort to perform even single targeted gene manipu-
lations is significant, and the complexity of the organism
prevents in many cases the detailed analyses of the KO
consequences. Here, the nematode C. elegans offers
several advantages: 40-60 % of the human disease
genes are represented by homologues in C. elegans. In
addition, the animals are small enough to be kept in
large numbers in a format that allows mass manipula-
tions (microtiter plates) and knock-outs of candidate
genes can be obtained in a matter of 4-6 weeks. Animal
facilities are cheap, and C. elegans is the only multicel-
lular organism for which the development of each single
cell and the entire connectivity of its nervous system are
known. At the same time, the cellular diversity of the C.
elegans nervous system is in the same range as that of
a vertebrate brain, although the total number of neurons
is only 302. Remarkably, C. elegans neurons use the
same neurotransmitters as humans, and the receptor
pharmacology is astonishingly similar.
In this seminar, examples of functional conservation of
human genes and their C. elegans counterparts/homo-
logues will be discussed. In particular, I will focus on
genes involved in human neurodegenerative diseases
and discuss the contribution C. elegans models can
make to understand the function of the relevant human
GENE TECHNOLOGY FORUM 2001 TARTU, ESTONIA
October newsletter For Alpha Kindergarten (Fletton Setting) 2013 We would like to welcome all our new children and families throughout the nursery not forgetting the return of some families with their new additions! We have some exciting news that Lisa has had a baby girl called Paige and Jess has had baby boy congratulations to both families. For those of our family’s who do not know Lizz
Homogeneity of Variances By Dr. Jon Starkweather, Research and Statistical Support consultant This month we touch on a fundamental issue in statistical evaluation that often gets overlooked. Testing assumptions for parametric analysis is a fundamental step and a necessary one. For example, let’s consider some of the simplest experimental design analysis available; the independent t- te
1995-2000 Group leader at the Genzentrum of the
since Nov. 2000 Professor of Biochemistry at the
Karolinska Institute Stockholm, Sweden.