Tadalafil zeigt eine konstante Resorption im Gastrointestinaltrakt, mit maximalen Plasmaspiegeln nach rund zwei Stunden. Der Wirkstoff verteilt sich gut im Gewebe und weist eine hohe Plasmaproteinbindung auf. Seine lange Halbwertszeit erlaubt eine verlängerte Wirkphase. Der Metabolismus erfolgt über das hepatische Enzymsystem CYP3A4, mit der Bildung inaktiver Metaboliten. Exkretion geschieht primär über den Stuhl. Die Häufigkeit von Nebenwirkungen steigt mit der Dosis, wobei vor allem vasodilatatorische Effekte dominieren. Ein gängiger Bezugspunkt in pharmakologischen Analysen ist cialis ohne rezept, das mit dieser Wirkstoffklasse assoziiert ist.

2003(平成15年)

2003(平成 15 年)
Original Articles
1) Site-specific arrhythmogenesis in patients with Brugada syndrome.
Morita H, Fukushima-Kusano K, Nagase S, Takenaka-Morita S, Nishii N, Kakishita M,
Nakamura K, Emori T, Matsubara H, Ohe T.
J Cardiovasc Electrophysiol. 2003 Apr;14(4):373-9.
2) Risk stratification for asymptomatic patients with Brugada syndrome.
Morita H, Takenaka-Morita S, Fukushima-Kusano K, Kobayashi M, Nagase S,Kakishita
M, Nakamura K, Emori T, Matsubara H, Ohe T.
Circ J. 2003 Apr;67(4):312-6.
3) Epinephrine unmasks latent mutation carriers with LQT1 form of congenital
long-QT syndrome.
Shimizu W*, Noda T*, Takaki H*, Kurita T*, Nagaya N*, Satomi K*, Suyama K*, Aihara N*,
Kamakura S*, Sunagawa K*, Echigo S*, Nakamura K, Ohe T, Towbin JA*, Napolitano C*, Priori SG*.
J Am Coll Cardiol. 2003 Feb 19;41(4):633-42.
4) Investigation of the optimal treatment strategy for atrial fibrillation in Japan.
Yamashita T*, Ogawa S*, Aizawa Y*, Atarashi H*, Inoue H*, Ohe T, Okumura K*, Kato T*,
Kamakura S*, Kumagai K*, Kurachi Y*, Kodama I*, Koretsune Y*, Saikawa T*, Sakurai M*, Sugi K*, Nakaya H*, Nakayama T*, Hirai M*, Fukatani M*, Mitamura H*, Yamazaki T*.
Circ J. 2003 Sep;67(9):738-41.
5) Ventricular arrhythmia induced by sodium channel blocker in patients with
Brugada syndrome.
Morita H, Morita ST, Nagase S, Banba K, Nishii N, Tani Y, Watanabe A, Nakamura K,
Kusano-Fukushima K, Emori T, Matsubara H, Hina K*, Kita T*, Ohe T.
J Am Coll Cardiol. 2003;42:1624-1631.
6) Living-donor lobar lung transplantation for various lung diseases.
Date H*, Aoe M*, Nagahiro I*, Sano Y*, Andou A*, Matsubara H, Goto K*, Tedoriya T*,
Shimizu N*.
J Thorac Cardiovasc Surg. 2003 Aug;126(2):476-81.
7) The Pressor Effect of Electroacupuncture on Hemorrhagic Hypotension.
Syuu Y*, Matsubara H, Hosogi S, Suga H*.
Am J Physiol Regul Integr Comp Physiol. 2003 Dec;285(6):R1446-52.
8) Direct evidence for increased hydroxyl radicals in angiotenisn II-induced cardiac
hypertrophy through angioteisin II type 1a receptor.
Kakishita M, Nakamura K, Asanuma M*, Morita H, Saito H, Kusano K, Nakamura Y,
Emori T, Matsubara H, Sugaya T*, Ogawa N*, Ohe T.
J Cardiovasc Pharm. 2003; 42(Suppl.1): S67-S70.
9) Tissue factor expression in atrial endothelia associated with nonvalvular atrial
fibrillation: possible involvement in intracardiac thrombogenesis.
Nakamura Y, Nakamura K, Fukushima-Kusano K, Ohta K, Matsubara H, Hamuro T*,
Yutani C*, Ohe T.
Thromb Res. 2003 Sep;111(3):137-42.
10) An X-ray diffraction study on contraction of rat papillary muscle with different
afterloads.
Okuyama H*, Yagi N*, Toyota H*, Araki J*, Shimizu J*, Iribe G*, Nakamura K, Mohri S*,
Kakishita M, Hashimoto K, Morimoto T*, Tsujioka K*, Kajiya F*, Suga H*.
Adv Exp Med Biol.2003;538:533-9.
Case Reports
1) Clusters of ventricular fibrillation in a patient with an implantable cardioverter
difibrillator treated with amiodarone.
Emori T, Ohta K, Kusano K, Morita H, Matsubara H, Sano S*, Ohe T.
Circ J. 2003 Feb;67(2):163-5.

Source: http://cardio.icn.jp/a/04/2003.pdf

Microsoft word - travelers first aid kit_11.03.06.doc

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