MATERIAL SAFETY DATA SHEET Date Printed: 10/19/2006 Date Updated: 05/25/2006 Version 1.8
Section 1 - Product and Company Information
Product Name AMPICILLIN SODIUM SALT Product Number APAM-0001
Brand SIAL Company Sigma-Aldrich Address 3050 Spruce Street SAINT LOUIS MO 63103 US Technical Phone: 800-325-5832 Fax: 800-325-5052 Emergency Phone: 314-776-6555
Section 2 - Composition/Information on Ingredient Substance Name CAS # SARA 313 AMPICILLIN SODIUM 69-52-3 No Formula C16H18N3NaO4S Synonyms Alpen-N * Amcill-S * D(-)-alpha-Aminobenzylpenicillin sodium salt * Ampicillin sodium * Ampicillin sodium salt * Binotal sodium * Citteral * Domicillin * Omnipen-N * PEN A/N * Penbritin-S * Penialmen * Polycillin-N * Principen/N * Sodium D-(-)-alpha-aminobenzylpenicillin * Sodium amipicillin * Sodium binotal * Sodium P-50 RTECS Number: XH8400000 Section 3 - Hazards Identification EMERGENCY OVERVIEW Irritant.
May cause sensitization by inhalation and skin contact.
HMIS RATING HEALTH: 3* FLAMMABILITY: 0 REACTIVITY: 1 NFPA RATING HEALTH: 3 FLAMMABILITY: 0 REACTIVITY: 1 *additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures ORAL EXPOSURE If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
DERMAL EXPOSURE In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures AUTOIGNITION TEMP N/A FLAMMABILITY N/A EXTINGUISHING MEDIA Suitable: Water spray. Carbon dioxide, dry chemical powder, or appropriate foam.
FIREFIGHTING Protective Equipment: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures PROCEDURE(S) OF PERSONAL PRECAUTION(S) Wear respirator, chemical safety goggles, rubber boots, and heavy rubber gloves.
METHODS FOR CLEANING UP Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Section 7 - Handling and Storage HANDLING User Exposure: Avoid breathing dust. Avoid contact with eyes, skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE Suitable: Keep tightly closed.
Store at 2-8°C SPECIAL REQUIREMENTS Hygroscopic.
Section 8 - Exposure Controls / PPE ENGINEERING CONTROLS Mechanical exhaust required. SIAL - A9518 www.sigma-aldrich.com Page 2
PERSONAL PROTECTIVE EQUIPMENT Respiratory: Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Where risk assessment shows air-purifying respirators are appropriate use a dust mask type N95 (US) or type P1 (EN 143) respirator.
Other: Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
GENERAL HYGIENE MEASURES Wash thoroughly after handling. Wash contaminated clothing before reuse.
Section 9 - Physical/Chemical Properties Appearance Physical State: Solid Color: Slightly yellow Property Value At Temperature or Pressure Molecular Weight 371.39 AMU pH N/A BP/BP Range N/A MP/MP Range 215 °C Freezing Point N/A Vapor Pressure N/A Vapor Density N/A Saturated Vapor Conc. N/A SG/Density N/A Bulk Density N/A Odor Threshold N/A Volatile% N/A VOC Content N/A Water Content N/A Solvent Content N/A Evaporation Rate N/A Viscosity N/A Surface Tension N/A Partition Coefficient N/A Decomposition Temp. N/A Explosion Limits N/A Flammability N/A Autoignition Temp N/A Refractive Index N/A Optical Rotation Degree of Rotation: 20 °C 2 g/l Solvent: H2O +255 (+-5) Miscellaneous Data N/A Solubility Solubility in Water:50 mg/ml H2O clear, very faintly yellow N/A = not available Section 10 - Stability and Reactivity STABILITY Stable: Stable.
Conditions to Avoid: Moisture.
Materials to Avoid: Oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide, SIAL - A9518 www.sigma-aldrich.com Page 3
Nitrogen oxides, Sulfur oxides.
HAZARDOUS POLYMERIZATION Hazardous Polymerization: Will not occur Section 11 - Toxicological Information ROUTE OF EXPOSURE Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
SENSITIZATION Sensitization: There are reports of serious and sometimes fatal hypersensitivity (anaphylactic) reactions occurring in people receiving penicillin therapy by the parenteral route although it has also occurred via oral administration. These reactions usually occur in individuals who have a history of sensitivity to multiple allergens, asthma, hay fever or urticaria. Ingestion has resulted in nausea, vomiting, diarrhea, glossitis, stomatitis, enterocolitis, pseudomembranous coloitis.
Hypersensitivity reactions: erythematous maculopapular rashes, erythema multiforme, urticaria and exfoliative dermatis.
Respiratory: May cause allergic respiratory reaction.
Skin: May cause allergic skin reaction.
SIGNS AND SYMPTOMS OF EXPOSURE To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
TOXICITY DATA Oral Rat > 5314 mg/kg LD50 Intraperitoneal Rat 7400 MG/KG LD50 Subcutaneous Rat >5314 MG/KG LD50 Oral Mouse > 5314 mg/kg LD50 Intraperitoneal Mouse 5700 MG/KG LD50 Subcutaneous Mouse SIAL - A9518 www.sigma-aldrich.com Page 4
>5314 MG/KG LD50 CHRONIC EXPOSURE - CARCINOGEN Result: This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC, ACGIH, NTP, or EPA classification.
IARC CARCINOGEN LIST Rating: Group 3 Group 3 Rating: Group 3 Section 12 - Ecological Information No data available.
Section 13 - Disposal Considerations APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations.
Section 14 - Transport Information DOT Proper Shipping Name: None Non-Hazardous for Transport: This substance is considered to be non-hazardous for transport.
IATA Non-Hazardous for Air Transport: Non-hazardous for air transport.
Section 15 - Regulatory Information EU ADDITIONAL CLASSIFICATION Symbol of Danger: Xi Indication of Danger: Irritant.
R: 42/43 Risk Statements: May cause sensitization by inhalation and skin contact.
S: 22-36/37-45 Safety Statements: Do not breathe dust. Wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
US CLASSIFICATION AND LABEL TEXT Indication of Danger: Irritant.
Risk Statements: May cause sensitization by inhalation and skin contact.
Safety Statements: Wear suitable protective clothing and gloves.
Do not breathe dust. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
UNITED STATES REGULATORY INFORMATION SARA LISTED: No CANADA REGULATORY INFORMATION SIAL - A9518 www.sigma-aldrich.com Page 5
WHMIS Classification: This product has been classified in accordance with the hazard criteria of the CPR, and the MSDS contains all the information required by the CPR.
DSL: No NDSL: No Section 16 - Other Information DISCLAIMER For R&D use only. Not for drug, household or other uses.
WARRANTY The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Inc., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.
Copyright 2006 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only.
SIAL - A9518 www.sigma-aldrich.com Page 6
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