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1. DAY - Wednesday, 19 March 2014, 15:30h Chairs: Kenneth Murphy, Ari Waisman TSLP-elicited basophil responses mediate the pathogenesis of eosinophilic esophagitis TLR expression and functional profiling in human basophils of allergic vs non-allergic donors Pollen substances provoke inflammasome activation in human keratinocytes The role of innate immunity in the control of Legionella pneumophila lung infection The role of innate immune receptor NOD2 in atherosclerosis Non-canonical binding and function of the TLR2 ligand Pam3Cys Chairs: Annette Oxenius, Andreas Radbruch Co-receptor-Lck coupling sets the pMHC-TCR dwell time threshold for negative selection Composing diverse T cell responses out of individual precursors CD4+ T cell derived IL-10 is independent of IL-27 signaling in a recall response T cell differentiation in chronic infection – functional adaptation or exhaustion?ANNexin-V Associated and tolerance induction by CD4+T-cells Suppressor T cells: phosphatidylserine recognition as a link between Memory T cells require post-transcriptional regulation to preclude aberrant cytokine production Chairs: Benjamin Marsland, Anne MüllerAbsence of IFNgamma protects from innate driven, but not from CD4 T cell-induced colitis and leads to a preferential differentiation of transferred CD4 T cells into Th17 T cells Virus-associated activation of innate immunity induces rapid disruption of Peyer’s patches in mice MyD88-dependent conditioning of Peyer’s patch fibroblastic reticular cells regulates intestinal pathogen control Monocytes differentiate into macrophages and lymph node-homing dendritic cells in human gut Defective neonatal oral tolerance is due to physiological neonatal Vitamin A deficiency Age related gut dysbiosis contributes to age related colitis and colon cancer risk through a potentially B7-H1-dependent mechanism Workshop 4: Metabolism and immune response Chairs: Giuseppe Matarese, Erika Pearce Thioredoxin reductase-1 is essential for expansion of T cells in viral infection A regulatory role for lamina propria cells and intestinal inflammation in obesity in absence of MyD88 signaling Endotoxin tolerance  as a novel defense strategy in infectious diseases: the role of tryptophan catabolismThe novel strategy for osteoclast manipulation; discovery of "osteoclast fusion inhibitor" and its potential for prophylaxis against bone Hypomorphic, homozygous mutations in phosphoglucomutase 3 impair immunity and increase serum IgE levels in patients from highly The (potential) role of apolipoproteins in nasal mucus of allergic rhinitis patients Role of EBI2 and oxysterols in the pathogenesis of fatty Liver disease Poster presentations of workshops 1 - 4, Room Main Corridor Chairs: Annika Scheynius, Shizuo Akira Trautwein-Weidner IL-17-mediated control of oral fungal infection is independent of neutrophil recruitment Negative regulation of IL-6 and IL-10 mediated STAT3 activation by NOD1 The death pathway leading to eosinophil cytolysis Getting to the inflammation site, matricellular CCN1 paves the way for monocytes and neutrophils Leptin-induced cross tolerance to TLR-3 and TLR-7 in human PBMCs and U937 monocytes Supression of interferon responses by tick salivary cystatins in dendritic cells Chairs: Florent Ginhoux, Richard BlumbergCharacterization of a thymic stromal lymphopoietin (TSLP)-responsive dendritic cell (DC) subset in human airway mucosa and its role in upper airway allergyThe combined action of Aryl hydrocarbon receptor and RelB controls long term expression of indoleamine 2,3-dioxygenase-1 in splenic dendritic cellsNotch4 signaling affects development, survival and maturation of human plasmacytoid dendritic cells thereby controlling their T cell Molecular mechanisms of modulation of human LC function by epidermal cytokines in allergic skin inflammationLung neonatal responses to respiratory syncytial virus reveal deficiencies in dendritic cells and type I interferon in a mouse model of airway enhanced diseaseDietary intervention with specific non-digestible oligosaccharides and Bifidobacterium breve M-16V supports the development of tolerogenic DC in a murine model for food allergy Role of the thymus in immunosuppression of antigen-driven autoimmunity by plasmacytoid dendritic cells Workshop 7: T cell subsets and effector mechanisms Chairs: Michael Bevan, Dirk Busch The combined expression of the surface markers TIGIT and FcRL3 accurately discriminates between Helios+ and Helios- human memory The role of adenosine production in regulation of helper T cellsTransforming growth factor-beta signaling in T cells promotes stabilization of atherosclerotic plaques through an interleukin-17 dependent T cell specific loss of PTPN2 leads to miss-balanced T helper cell differentiation resulting in aggravated intestinal inflammation The role of T follicular helper cells during persistent LCMV infection Depletion of regulatory T cells in the APCmin/+ mouse model of colon cancer enhances Th1 associated immune responses The roles for DOCK2 and PI3Kgamma during CD4+ T cell – dendritic cell interactions and subsequent activation in vivo The threshold hypothesis: a PAMP-independent mechanism that generally determines the Th1/Th2 phenotype of an immune response Workshop 8: Epigenetic control of immune response Chairs: Frode Jahnsen, Richard Flavell Effects of isotretinoin treatment on epigenetic programming in T cells and murine gut microbiota composition Epigenetic control of mast cell proliferation and disease Revealing the epigenetic regulation of macrophage differentiation and polarization through multidimensional phenotypic RNAi screens Reactive oxygen species prevent imiquimod-induced psoriatic dermatitis through enhancing regulatory T cell function Epigenetic changes during T cell development Chromatin talks to inflammation: IL-1alpha senses DNA damage and signal for genotoxic stress Epigenetic mechanisms for weaker expression of tight junctions in bronchial epithelial cells from asthmatic individuals? Poster presentations of workshops 5 - 8, Room Main Corridor 3. DAY - Friday, 21 March 2014, 15:00h/15:30h Chairs: Hergen Spits, Gleb Turchinovich Impact of innate lymphoid cells on the tumour microenvironment Human fetal innate lymphoid cells defined by transcription factor expression at the single cell level reveals distinct developmental Skin induced group 3 innate lymphoid cells efficiently control asthma via modulation of stromal cell function by IL-22 Innate lymphoid cell (ILC) reconstitution after allogeneic stem cell transplantation: association with prevention of graft versus host disease Innate lymphoid cells correlate with viral load setpoint in HIV infection Innate lymphoid cells elicit T cell responses upon inflammation The TNF family cytokine TL1A: a key player in type 2 immunity in both adaptive and innate lymphocytes Role of IL-33 and innate immune cells in tumor suppression Workshop 10: Immune regulatory mechanisms related to resident tissue cells Chairs: Georgios Belibasakis, Karl Schenck Characterization of the healthy interaction between the human immune cells and the pancreatic islet Influence of IL-15 on CD8aa+ TCRab+ intestinal intraepithelial lymphocytes in vitro and in vivo Antigen and adjuvant trafficking within and outside of early life lymph nodes Selective retention of effector memory CD8+ T cells within human spleen Notch dependent generation of CD4+ T regulatory cells by hepatocytes Chemerin modifications in human epidermis Workshop 11: Effector and regulatory T cells Chairs: Pamela Schwartzberg, Kenji Kabashima Targeting apoptosis to shift the regulatory/effector T cell balance towards toleranceCombining regulatory T cell depletion and inhibitory receptor blockade improves reactivation of exhausted virus-specific CD8+ T cells and efficiently reduces chronic retroviral loadsHigh eomesodermin expression among CD57+ CD8 T cells identifies a CD8 T cell subset associated with viral control during human Control of the regulatory T cell lineage by PTEN Unraveling hFOXP3 function in physiological and pathological lymphoid cell development Plasmodium falciparum-induced CD4+CTLA4+PD1+ T effector cells coproduce IFNg and IL-10 and suppress CD4+ T cell responses in Lipid raft localization of Fas/CD95 distinguishes apoptotic from non-apoptotic receptor signaling in vivo Workshop 12: Biologicals and in vivo immune modulation Chairs: Sefik Alkan, Mladen Mercep Blocking junctional adhesion molecule C enhances dendritic cell migration and improves immune response against Leishmania major Intratumoral application of interleukin-12 reduces tumor growth and pulmonary metastasis in a mouse model of metastatic breast cancerReduced short-term allogeneic cytotoxic immune response after therapeutic blockade of LIGHT interaction with HVEM and lymphotoxin Abatacept decreases disease activity in the absence of CD4+ T cells in the collagen induced arthritis model Pathogenic and protective effects of Candida albicans and Acinetobacter lwoffii in a murine model of atopic dermatitis Inert polystyrene nanoparticles downregulate inflammatory signaling pathways and alter immunoregulatory cell proportions in the lung The role of non-neutralizing but opsonizing anti influenza antibodies in immunity against heterosubtypic influenza virus Poster presentations of workshops 9 - 16, Room Main Corridor Workshop 13: B cells and immune regulation Chairs: Michael McHeyzer-Williams, Christoph HeusserB cell activating factor (BAFF) and BAFF-R levels correlate with B cell subset activation and redistribution in controlled human malaria Characterization of human antigen-specific B cell subsets Characterization of a novel genetic defect causing antibody deficiencyTick-borne encephalitis and hepatitis B non-responders feature different immunologic mechanisms in response to TBE and influenza vaccination with involvement of regulatory T and B cells and IL-10 The PD-1/PD-L2 pathway programs Th2 cells towards an intrinsically tolerised phenotype resulting in susceptibility to helminth infection McHeyzer-WIlliams Multi-potent memory B cells re-program immune function at antigen recall Workshop 14: Immune regulation in the clinical settings: allergy and asthma Chairs: Thomas Kündig, Marek Leslek Kowalski Modulation of IgE mediated reactions by FcgammaRII High proportion of CD5+ B cells in infants predicts development of allergy On the hunt for pollen-derived (glyco-)lipids in the allergic inflammationRetinoic acid-differentiated dendritic cell induce Foxp3- regulatory T cells and reverse food allergen sensitivity in mouse models of Inhibition of allergen-induced colitis in a PBMC-engrafted murine model of allergy by activated GARP+ regulatory T cells Cellular stress caused by disturbed lipid metabolism in fetal skin predisposes for development of allergic disorders Workshop 15: Immune tolerance in autoimmunity and transplantation Chairs: Günnur Deniz, Nathan Karin Association of FOXP3 polymorphisms with GAD65 autoantibodies in type 1 diabetesIFN-gamma produced by Th1 cells activates inflammatory monocytes and stromal fibroblasts, which control effector function of autoreactive CD4+ T cells in mouse model of experimental autoimmune myocarditisCXCL11 regulates the dynamics of inflammatory autoimmunity by inducing novel IL-10high CD4+ Tr1-like T cells: basic research and clinical implications in experimental autoimmune encephalomyelitis Human eosinophils from hematopoietic stem cell transplant recipients decrease allogeneic T cell proliferation in a model of graft-versus- Dual inhibition of tumor necrosis factor receptor-1 and type I IFN-receptor-1 signaling in imiquimod-induced psoriasis Mechanisms of pregnancy-induced tolerance in an animal model of multiple sclerosis Workshop 16: Development of novel vaccines and drugs Chairs: Steen Klysner, Hans Grönlund Self-adjuvanted RNActive® vaccine induces innate immune response at the site of injection that leads to a potent adaptive immunity in Prolongued immune stimulation by means of calcium phosphate spheresComparison of subcutaneous and intramuscular application of a tick-borne encephalitis vaccine in healthy vaccinees: characterization of cellular and humoral vaccine specific immune responses Tolerogenic dendritic cells generated by in vitro treatment with SAHA are not stable in vivoEffective treatment of allergic asthma by tolerization with Helicobacter pylori-derived immunomodulators requires BATF3-dependent Antigen-loaded Exosomes and Microvesicles induce different immune responses in vivo

Source: http://www.wirm.ch/WTM/Workshops_files/Workshop_Programme_FinalBook.pdf

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