Phs 398 (rev. 9/04), biographical sketch format page

Principal Investigator/Program Director (Last, First, Middle): BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) University of North Carolina-Chapel Hill, NC
A. Positions and Honors
Assistant Research Biochemist, Biological Chemistry, Univ. of Michigan Instructor of Biological Chemistry, University of Michigan Assistant Professor of Biochemistry and Molecular Biology, University of Texas Medical School at Associate Professor of Biochemistry and Molecular Biology, University of Texas Medical School at Professor of Biochemistry and Molecular Biology, University of Texas Medical School at Houston S. Keith Johnson Science Award, College of Charleston John P. McGovern Outstanding Teacher Award, Graduate School of Biomedical Sciences for Teaching, University of Texas Health Science Center
B. Selected peer-reviewed publications (in chronological order).

Rowlands, J.C., Wang, H., Hakkak, R., Ronis, M.J.J., Strobel, H.W., and Badger, T.M.: Chronic Intragastric Infusion
of Ethanol-Containing Diets Induces CYP3A9 while Decreasing CYP3A2 in Male Rats, Journal of Pharmacology and Experimental Therapeutics, 295: 747-752, 2000. Cui, X, Nelson, D.R., Strobel, H.W.: A Novel Human Cytochrome P450 4F Isoform (CYP4F11): cDNA Cloning
Expression and Genomic Structure Characterization, Genomics, 68:161-166, 2000.
Wang, H., Napoli, K.L., and Strobel, H.W.: Cytochrome P450 3A9 Catalyzes the Metabolism of Progesterone and
other Steroid Hormones, Molecular and Cellular Biochemistry, 213:127-135, 2000. Cvrk, T., and Strobel, H.W.: Role of LYS271 and LYS279 Residues in the Interaction of Cytochrome P4501A1 with
NADPH-Cytochrome P450 Reductase, Archives of Biochemistry and Biophysics, 385: 290-300, 2001.
Cui, X., Kawashima, H., Barclay, T.B., Peters, J.M., Gonzalez, F.J., Morgan, E.T., Strobel, H.W.: Molecular Cloning
and Regulation of Expression of Two Novel Mouse CYP4F Genes Expression in PPARα Deficient Mice upon
LPS and Clofibrate Challenges, Journal of Pharmacology and Experimental Therapeutics, 296: 547-555, 2001.
Boehme, C.L., Strobel, H.W.: In Vitro Metabolism of Chlorpromazine by Cytochromes P450 4F4 and 4F5 and the
Inhibitory Effect of Imipramine, Neurotoxicity Research, 3:329-337, 2001.
Thompson, C.M., Capdevila, J.H. and Strobel, H.W.: Recombinant Cytochrome P450 2D18 Metabolism of
Dopamine and Arachidonic Acid, Journal of Pharmacology and Experimental Therapeutics, 294:1120-1130,
2000.
Biographical Sketch Format Page
Investigator/Program Director (Last, First, Middle): Cui, X, Nelson, D.R., Strobel, H.W.: A Novel Human Cytochrome P450 4F Isoform (CYP4F11): cDNA Cloning
Expression and Genomic Structure Characterization, Genomics, 68:161-166, 2000.
Cui, X., Kawashima, H., Barclay, T.B., Peters, J.M., Gonzalez, F.J., Morgan, E.T., Strobel, H.W.: Molecular Cloning
and Regulation of Expression of Two Novel Mouse CYP4F Genes Expression in PPARα Deficient Mice upon
LPS and Clofibrate Challenges, Journal of Pharmacology and Experimental Therapeutics, 296: 547-555, 2001.
Cvrk, T., and Strobel, H.W.: Role of THR501 Residue in substrate binding and catalytic activity of cytochrome
P4501A1, Archives of Biochem and Biophysics, 389: 31-40, 2001
Vasquez, H., Seifert, W. and Strobel, H.W.: High-performance liquid chromatographic method with electrochemical
detection for the analysis of O6 -methylguanine, Journal of Chromatography B, 759:185-190, 2001.
Nieman, L.Z., Kvale, J., Fu, X., Gu, Y. and Strobel, H.W.: Bringing a Family Practice Model of Health to the
People's Republic of China, Family Medicine, 33: 696-701, 2001.
Vasquez, H. and Strobel, H.W.: Role of cytochrome P450 in DNA damage produced by treatment of colon cells with
1,2-dimethylhydrazine, International Journal of Oncology, 18: 553-557, 2001.
Kalsotra, A., Anakk, S., Boehme, C.L. and Strobel, H.W.: Sexual Dimorphism and tissue specificity in the
expression of CYP4F forms in Sprague Dawley rats, Drug Metabolism and Disposition, 30:1022-1028, 2002.
Cui, X., Strobel, Henry W.: Cloning and characterization of the rat cytochrome P450 4F5 (CYP4F5) gene, Gene,
297: 179-187, 2002.
Cui, X., Strobel, Henry W.: Cloning and characterization of the rat cytochrome P450 4F5 (CYP4F5) gene, Gene,
297:179-187, 2002.
Cui, X., Kalsotra, A., Robida, A.M. Matzilevich, D., Moore, A.N. Boehme, C.L., Morgan, E.T., Dash, P.K. and Strobel, H.W.: Expression of Cytochromes 4F4 and 4F5 in Infection and Injury Models of Inflammation,
Biochemica et Biophysica Acta, 1619:325-331, 2003.
Anakk, S., Ku, C.Y., Vore, M and Strobel, H.W.: Insights into gender bias: rat cytochrome P4503A9, Journal of
Pharmacology and Experimental Therapeutics, 305:703-9, 2003.
Cui, X., Kalsotra, A., Robida, A.M. Matzilevich, D., Moore, A.N. Boehme, C.L., Morgan, E.T., Dash, P.K. and Strobel, H.W.: Expression of Cytochromes 4F4 and 4F5 in Infection and Injury Models of Inflammation,
Biochemica et Biophysica Acta, 1619: 325-331, 2003.
Kalsotra, A., Cui, X., Antonovic, L., Robida, A.M., Morgan, E.T. and Strobel, H.W.: Inflammatory prompts produce
isoform-specific changes in the expression of leukotriene B4 W-hydroxylases in rat liver and kidney, FEBS
Letters, 555: 236-242, 2003.
Anakk, S., Ku, C.Y., Vore, M. and Strobel, H.W.: Insights into Gender Bias: Rat Cytochrome P450 3A9, Journal of
Pharmacology & Experimental Therapeutics, 305:703-9, 2003.
Anakk, S., Kalsotra, A., Shen, Q., Vu, M.T., Staudinger, J.L., Davies, P.J.A., and Strobel, H.W.: Genomic
characterization and regulation of CYP3a13: role of xenobiotics and nuclear receptors, FASEB J., 17:1736-1738;
2003, published online as 10.1096/fj.02-1004fje
Kalsotra, A., Turman, C.M., Dash, P., and Strobel, H.W.: Differential effects of traumatic brain injury on the
Cytochrome P450 system: A perspective into hepatic and renal drug metabolism, Journal of Neurotrauma, 20:
236-242, 2003.
Anakk, S., Kalsotra, A., Kikuta, Y., Huang, W., Zhang, J., Staudinger, J.L., Moore, D.D. and Strobel, H.W.:
CAR/PXR provide directives for CYP 3a41 gene regulation differently from CYP3a11, The Pharmacogenomics
Journal, 4: 91-101, 2004.
Kalsotra, A., Turman, C.M., Kikuta, Y., and Strobel. H.W.: Expression and Characterization of Human Cytochrome
P450 4F11: Putative Role in the Metabolism of Therapeutic Drugs and Eicosanoids, Toxicology and Applied
Pharmacology, 199: 295-304, 2004.
Williams, E.T., Rodin, A.S. and Strobel, H.W.: Defining Relationships Between the Known Members of the
Cytochrome P450 3A Subfamily, Including Five Putative Chimpanzee Members, Molecular Phylogenetics and
Evolution, 33: 300-308, 2004.
Williams E.T., Leyk, M., Wrighton, S.A., Davies, P.J., Loose, D.S., Shipley, G.L. and Strobel, H.W.: Estrogen
Regulation of the Cytochrome P450 3A Subfamily in Humans, Journal of Pharmacology and Experimental
Therapeutics, 311: 728-735, 2004.
Williams, E.T., Turman, C.M. and Strobel, H.W.: NAMD-LP: Filtering and Translating NAMD-Generated Files.
Molecular Simulation, 31: 67-68, 2005.
Chinta, S.J., Kommaddi, R.P., Turman, C.M., Strobel, H.W., and Ravindranath, V. Constitute expression and localization of cytochrome P4501A1 in rat and human brain: Presence of splice variant form in human brain.
Journal of Neurochemistry, 93: 724-736, 2005
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Investigator/Program Director (Last, First, Middle): Richardson, T.A., Sherman, M., Antonovic, L., Karder, S.S., Strobel, H.W., Kalman, D., and Morgan, E.T. Hepatic
and Renal Cytochrome P450 Gene Regulation During Citrobacter Rodentium Infection in Wild-Type and Toll-like
Receptor 4 Mutant Mice. Drug Metabolism and Disposition 34: 354-360, 2006.
Anakk, S., Huang, W., Staudinger, J.L., Tan, K., Cole, T.J., Moore, D.D. and Strobel, H.W. Gender Dictates the
Nuclear Receptor-Medicated Regulation of CYP 3A44. Drug Metabolism and Disposition 35: 2006.
Kalsotra, A., Zhao, J., Anakk, S., Dash, P.K., and Strobel, H.W. Brain Trauma Leads to Enhanced Lung
Inflammation and Injury: Evidence for Role of P450 4F’s in Resolution. Journal of Cerebral Blood Flow and
Metabolism. In Press, 2006.
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