Es ist nicht klar, wie groß die Rolle von Antibiotika https://antibiotika-wiki.de/ in den Wettbewerbsbeziehungen zwischen Mikroorganismen unter natürlichen Bedingungen ist. Zelman vaxman glaubte, dass diese Rolle minimal ist, Antibiotika werden nicht anders als in reinen Kulturen auf reichen Umgebungen gebildet. Anschließend wurde jedoch festgestellt, dass bei vielen Produzenten die Aktivität der antibiotikasynthese in Gegenwart anderer Arten oder spezifischer Produkte Ihres Stoffwechsels zunimmt.

[en] - altibio rf 50 - 2008-04-1

MATERIAL SAFETY DATA SHEET
ALTIBIO RF 50
05158-021-USI
1. IDENTIFICATION OF THE SUBSTANCE/ PREPARATION AND OF THE COMPANY / UNDERTAKING
Watersoluble lubricant (see technical data sheet for more details).
CONDATAvenue Frédéric Mistral, B.P. 1638670 Chasse-Sur-RhôneFranceTél 33/ 4.78.07.38.38Fax 33/ 4.78.07.38.00 Emergency phone number
Official advisory body
Emergency telephone number of ORFILA/ INRS : + 33 1.45.42.59.59.
2. COMPOSITION/ INFORMATION ON INGREDIENTS
Concentrate with a mineral oil basis and wetting agents.
Sodium sulfonate with long alkyl aryl chain SEE SECTION 8 TOO FOR THE COMPONENTS WITH A EXPOSURE LIMIT VALUE. 3. HAZARDS IDENTIFICATION
Hazardous product according to 1999/45/EC or modified 67/548/EC regulations.
symbol(s) Quick-FDS [14768-69080-22183-267413] - 2008-06-06 - 19:11:20 MATERIAL SAFETY DATA SHEET
ALTIBIO RF 50
05158-021-USI
See Section(s) 12Harmful to aquatic organisms, may cause long-term adverse effects inthe aquatic environment.
4. FIRST-AID MEASURES
Take the victim out of polluted area and remove the victim to fresh air.
Call a physician if needed.
In case of eye contact, immediately rinse with clean water for 10-15minutes. See an ophtalmologist if necessary.
If swallowed, do not induce vomiting. Rinse mouth with water. Call aphysician if needed.
5. FIRE - FIGHTING MEASURES
Not specifically concernde (aqueous liquid).
6. ACIDENTAL RELEASE MEASURES
Wear suitable protective clothing and gloves.
See also chapter 8 Impound/recover large land spill.
Prevent entry to sewers and public waters.
Suck up the liquid. If the recovery is impossible or if the spillage is toosmall, absorb with sand or other inert absorbent.
Give soiled materials to an approved recuperator.
See also chapter 13 7. HANDLING AND STORAGE
Local exhaust ventilation may be required to meet exposurestandards in addition to general room ventilation.
Quick-FDS [14768-69080-22183-267413] - 2008-06-06 - 19:11:20 MATERIAL SAFETY DATA SHEET
ALTIBIO RF 50
05158-021-USI
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Sodium sulfonate with long alkyl aryl chain Oil mists (France) , VME = 1mg/m3 (CNAM/INRS 2002, France)VME = 5mg/m3, VLE = 10 mg/m3 (ACGIH 1998) Usual protection means : overalls, safety shoes 9. PHYSICAL AND CHEMICAL PROPERTIES
10. STABILITY AND REACTIVITY
Stable in normal storage and use conditions.
No hazardous reaction is known in normal use conditions. Seetechnical data sheet.
other than carbon monoxide , carbon dioxide :Nitrogen compoundsFormaldehyde in small quantities 11. TOXICOLOGICAL INFORMATION
Not classified harmful if swallowed.
Quick-FDS [14768-69080-22183-267413] - 2008-06-06 - 19:11:20 MATERIAL SAFETY DATA SHEET
ALTIBIO RF 50
05158-021-USI
Prolonged or repeated skin contact may lead to defatting of the skinand subsequent slight irritation and dermatitis.
12. ECOLOGICAL INFORMATION
PERSISTENCE AND DEGRADABILITYBiodegradation : ECOTOXICITYEffects to aquatic organisms : Harmful to aquatic organisms, may cause long-term adverse effects inthe aquatic environment.
13. DISPOSAL CONSIDERATIONS
Do not dispose of by means of sinks,drains or in the immediateenvironment.
Give to an approved recuperator for disposal.
Completely empty packaging before disposal.
14. TRANSPORT INFORMATION
Environmentally hazardous substance, liquid, nos Quick-FDS [14768-69080-22183-267413] - 2008-06-06 - 19:11:20 MATERIAL SAFETY DATA SHEET
ALTIBIO RF 50
05158-021-USI
15. REGULATORY INFORMATION
R36/38 - Irritating to eyes and skin.
R52/53 - Harmful to aquatic organisms, may cause long-term adverseeffects in the aquatic environment.
S26 - In case of contact with eyes, rinse immediately with plenty ofwater and seek medical advice.
S37/39 - Wear suitable gloves and eye/face protection.
S46 - If swallowed, seek medical advice immediately and show thiscontainer or label.
S61 - Avoid release to the environment. Refer to specialinstructions/safety data sheets.
OTHER REGULATORY PROVISIONSFRANCE - Decree of July 13, 2006Tables N° of work diseases (France) : French Social Security Code Art. L461-1 to L 461-8, tables no.:364949 bis84 Table N° of diseases in relation with work French Social Security Code Art. L461-6 + Art. D461-1, tables no.: 16. OTHER INFORMATION
ADVICE TO USERSThis form completes technical data sheet but does not replace it. The information contained herein is based on the data available to us andbelieved to be correct. We do not warrant or guarantee their accuracy or reliability and we are not liable for any loss or damage arisingout of the use thereof. The information and recommendations are offered for the users consideration and examination and it is the usersresponsability to satisfy itself that they are suitable and complete for its particular use. The whole regulation is only mentioned to help theaddresse, to perform it's duty when using a dangerous product. This list must not be considered as exhaustive and does not relieve theaddresse to verify that some other obligations do not fall on him according to some other texts concerning the holding or handling of theproduct he is responsible for.
List of R phrases mentioned in section 2 (phrases related to hazardous substances contained in the finishedproduct) :R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R21/22 - Harmful in contact with skin and if swallowed.
R22 - Harmful if swallowed.
R34 - Causes burns.
R36/38 - Irritating to eyes and skin.
Quick-FDS [14768-69080-22183-267413] - 2008-06-06 - 19:11:20 MATERIAL SAFETY DATA SHEET
ALTIBIO RF 50
05158-021-USI
R38 - Irritating to skin.
R41 - Risk of serious damage to eyes.
R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Quick-FDS [14768-69080-22183-267413] - 2008-06-06 - 19:11:20

Source: http://www.replenex.net/safety/msds/Condat/Altibio%20RF%2050%20MSDS%200408.pdf

Tcrm_3768_chapurlat.indd

Treatment of osteoporosis with annual iv zoledronic acid: effects on hip fracture Background: Several treatments for postmenopausal osteoporosis have been available in the past decade, but adherence to these treatments has been judged inadequate. The prevention of hip fracture by these medications is still modest. Methods: A literature search was performed for treatment with zoledronic aci

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