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(tacrolimus) capsules USP
Read this Patient Information before you start taking PROGRAF and each time you get a refill. There may be new information. This information does not take the place of talking with your doctor about your medical condition or your treatment.
What is the most important information I should know about PROGRAF?
Prograf can cause serious side effects, including:
1. Increased risk of cancer.
People who take Prograf have an increased risk of getting some kinds
of cancer, including skin and lymph gland cancer (lymphoma).
2. Increased risk of infection.
PROGRAF is a medicine that affects your immune system.
Prograf can lower the ability of your immune system to fight infections. Serious infections can
happen in people receiving Prograf that can cause death. Call your doctor right away if you
have symptoms of an infection such as:
cough or flu-like symptoms muscle aches
warm, red, or painful areas on your skin
. What is PROGRAF?
PROGRAF is a prescription medicine used with other medicines to help prevent organ rejection in people who
have had a kidney, liver, or heart transplant and PROGRAF is not for use with medicines called cyclosporines
(Gengraf®, Neoral®, and Sandimune®).
PROGRAF is not for use with a medicine called sirolimus (Rapamune®) in people who have had a liver or heart
It is not known if PROGRAF is safe and effective when used with sirolimus in people who have had kidney
It is not known if PROGRAF is safe and effective in children who have had a kidney or heart transplants.
Who Should Not Take PROGRAF?
Do not take PROGRAF if you
are allergic to tacrolimus or any of the ingredients in PROGRAF. See the end
of this leaflet for a complete list of ingredients in PROGRAF.
What should I tell my doctor before taking PROGRAF?
Before you take PROGRAF, tell your doctor if you:
have or have had liver, kidney or heart problems are pregnant or plan to become pregnant. PROGRAF may harm your unborn baby. Talk to your doctor
if you are pregnant or plan to become pregnant.
Are breastfeeding or plan to breastfeed. PROGRAF can pass into your breast milk. You and your doctor
should decide if you will take PROGRAF or breastfeed. You should not do both.
Tell your doctor about all the medicines you take,
including prescription and non-prescription medicines,
vitamins, and herbal supplements.
Especially tell your doctor if you take:
cyclosporine (Gengraf®, Neoral®, and Sandimune®) sirolimus (Rapamune®)
telaprevir (IncivekTM) boceprevir (VictrelisTM)
amiodarone (CordaroneTM, NexteroneTM, PaceroneTM)
Ask your doctor or pharmacist if you are not sure if you take any of the medicines listed above. PROGRAF may affect the way other medicines work, and other medicines may affect how PROGRAF works. Know the medicines you take. Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine.
How Should I Take PROGRAF?
Take PROGRAF exactly as your doctor tells you to take it.
Your doctor will tell you how many PROGRAF to take and when to take them.
Your doctor may change your PROGRAF dose if needed. Do not
stop taking or change your dose of
Take PROGRAF the same way everyday. For example, if you choose to take PROGRAF with food, you
Take PROGRAF at the same time each day, 12 hours apart. For example, if you take your first dose at
7:00 a.m. you should take your second dose at 7:00 p.m.
o Taking PROGRAF at the same time each day helps to keep enough medicine in your body to
give your transplanted organ the around-the-clock medicine it needs.
eat grapefruit or drink grapefruit juice while taking PROGRAF.
If you take too much PROGRAF, call your doctor or go to the nearest hospital emergency room right
What should I avoid while taking PROGRAF?
While you take PROGRAF you should not receive any live vaccines such as:
o flu vaccine through your nose o measles o mumps o rubella o polio by mouth o BCG (TB vaccine) o yellow fever o chicken pox (varicella) o typhoid
Avoid exposure to sunlight and UV light such as tanning machines. Wear protective clothing and use a
What are the possible side effects of PROGRAF?
PROGRAF may cause serious side effects, including:
See “What the most important information I should know about PROGRAF?”
high blood sugar (diabetes).
Your doctor may do certain tests to check for diabetes while you take
PROGRAF. Call your doctor right away if you have:
o frequent urination o increased thirst or hunger o blurred vision o confusion o drowsiness o loss of appetite o fruity smell on your breath o nausea, vomiting, or stomach pain
Your doctor may do certain tests to check your kidney function while you take
nervous system problems.
Call your doctor right away if you get any of these symptoms while taking
PROGRAF. These could be signs of a serious nervous system problem:
o muscle tremors
o numbness and tingling
o vision changes
high levels of potassium in your blood.
Your doctor may do certain tests to check your potassium level
high blood pressure.
Your doctor will monitor your blood pressure while you take PROGRAF.
heart problems (myocardial hypertrophy).
Tell your doctor right away if you get any of these
symptoms of heart problems while taking PROGRAF:
o shortness of breath o chest pain o feel lightheaded o feel faint
The most common side effects of PROGRAF in people receiving kidney transplant are:
tremors (shaking of the body) high blood pressure
low levels of phosphate in your blood swelling of the hands, ankles, or legs
pain high levels of fat in your blood
high levels of potassium in your blood
The most common side effects of PROGRAF in people receiving liver transplants are:
numbness or tingling in your hands or feet anemia
high levels of potassium in the blood
low levels of magnesium in the blood
The most common side effects of PROGRAF for heart transplant patients are:
Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of PROGRAF. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How should I store PROGRAF?
Store PROGRAF at 59º F to 86ºF (15°C to 30º C).
Safely throw away medicine that is out of date or no longer needed.
Keep PROGRAF and all medicines out of reach of children.
General information about the safe and effective use of PROGRAF
Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not
use PROGRAF for a condition for which it was not prescribed. Do not give PROGRAF to other people, even if
they have the same symptoms that you have. It may harm them. How Does PROGRAF Protect My New Organ?
The body’s immune system protects the body against anything that it does not recognize as part of the body.
For example, when the immune system detects a virus or bacteria it tries to get rid of it to prevent infection.
When a person has a liver, kidney, or heart transplant, the immune system does not recognize the new organ as
a part of the body and tries to get rid of it, too. This is called “rejection”. PROGRAF protects your new organ
by slowing down the body’s immune system.
This Patient Information leaflet summarizes the most important information about PROGRAF. If you would
like more information, talk with your doctor. You can ask your pharmacist or doctor for information about
PROGRAF that is written for health professionals.
For more information, go to www.astellas.com/us or call 1-800-727-7003. What are the ingredients in PROGRAF?
Active ingredient: tacrolimus
Inactive ingredients: lactose monohydrate, hypromellose, croscarmellose sodium, magnesium stearate, gelatin,
titanium dioxide and ferric oxide. This Patient Information has been approved by the U.S. Food and Drug Administration.
Product of Japan
Manufactured by: Astellas Ireland Co., Ltd.
Killorglin, County Kerry, Ireland
Marketed by: Astellas Pharma US, Inc.
Northbrook, IL 60062
Revised: September 2013
« PLASTIE MAMMAIRE D’AUGMENTATION PAR IMPLANTS PROTHETIQUES» Traitements médicaux : • Un traitement antalgique de base (PARACETAMOL) vous a été prescrit, il doit être pris de façon systématique pendant 10 jours. Un traitement antalgique plus puissant (TRAMADOL) est nécessaire pendant 48 heures ou plus suivant l’intensité des douleurs. • Un myorelaxant (TETRAZEPAM) est
Environmental Toxicology and Chemistry, Vol. 32, No. 12, pp. xx–xx, 2013ACUTE AND CHRONIC EFFECTS OF DIPHENHYDRAMINE ANDSERTRALINE MIXTURES IN CERIODAPHNIA DUBIAERIC W. GOOLSBY,y CHASE M. MASON,z JAMES T. WOJCIK,y ALEX M. JORDAN,y and MARSHA C. BLACK*yyDepartment of Environmental Health Science, University of Georgia, Athens, Georgia, USAzDepartment of Plant Biology, University of Georgia