Tadalafil zeigt eine konstante Resorption im Gastrointestinaltrakt, mit maximalen Plasmaspiegeln nach rund zwei Stunden. Der Wirkstoff verteilt sich gut im Gewebe und weist eine hohe Plasmaproteinbindung auf. Seine lange Halbwertszeit erlaubt eine verlängerte Wirkphase. Der Metabolismus erfolgt über das hepatische Enzymsystem CYP3A4, mit der Bildung inaktiver Metaboliten. Exkretion geschieht primär über den Stuhl. Die Häufigkeit von Nebenwirkungen steigt mit der Dosis, wobei vor allem vasodilatatorische Effekte dominieren. Ein gängiger Bezugspunkt in pharmakologischen Analysen ist cialis ohne rezept, das mit dieser Wirkstoffklasse assoziiert ist.
Plastech.cn
Foreign Medical Sciences Section on Pharmacy 1994-2008 China Academic Journal Electronic Publishing House. All rights reserved. http://www.cnki.net 1994-2008 China Academic Journal Electronic Publishing House. All rights reserved. http://www.cnki.netForeign Medical Sciences Section on Pharmacy 1994-2008 China Academic Journal Electronic Publishing House. All rights reserved. http://www.cnki.net 1994-2008 China Academic Journal Electronic Publishing House. All rights reserved. http://www.cnki.netForeign Medical Sciences Section on Pharmacy
Vidyasankar S , Ru M , Arnold FH. Molecularly imprinted
ligand2exchange adsorbents for the chiral separation of un2
derivatized amino acids [J ] . J Chromatogr A , 1997 , 775
Haupt K , Dzgoev A , Mosbach K. Assay system for the her2
bicide 2 , 42dichlorophenoxyacetic acid using a molecularly
imprinted polymer as an artificial recognition element [J ] . Anal Chem , 1998 , 70 (3) :628 - 631.
Olsen J , Martin P , Wilson ID , et al. Methodology for as2
sessing the properties of molecular imprinted polymers for
solid phase extraction[J ] . Analyst , 1999 , 124 (4) :467 -
Stevenson D. Molecular imprinted polymers for solid2phase
extraction[J ] . Trends Anal Chem , 1999 , 18 ( 3) : 154 -
Sreenivasan K. On the feasibility of using molecularly im2
printed poly ( Hema) as a sensor component [J ] . Talanta ,
RJ , Bode M , Shimizu KD. Measurement of the
continuous distribution of binding sites in molecularly im2
printed polymers [ J ] . Analyst , 2000 , 125 ( 7) : 1261 -
Sellergren B. Imprinted dispersion polymers : a new class of
easily accessible affinity stationary phases [ J ] . J Chro2
matogr , 1994 , 673 (1) :133 - 141.
Surugiu I , Ye L , Yilmaz E , et al . An enzyme2linked
molecularly imprinted sorbent assay [ J ] . Analyst , 2000 ,
Sellergren B. Direct drug determination by selective sample
enrichment on an imprinted polymer [ J ] . Anal Chem ,
Walshe M , Howarth J , Kelly MT. The preparation of a
molecular imprinted polymer to 72hydroxycoumarin and its
use as a solid2phase extraction material [ J ] . J PharmBiomed Anal , 1997 , 16 (2) :319 - 325.
serum by molecularly imprinted solid2phase extraction with
pulsed elution [J ] . Anal Chem , 1998 , 70 ( 17) : 3636 -
Rashid BA , Briggs RJ , Hay JN , et al . Preliminary evalua2
tion of a molecular imprinted polymer for solid2phase extrac2
1994-2008 China Academic Journal Electronic Publishing House. All rights reserved. http://www.cnki.net
82782449 , E2mail : acjpe 077 @public. wh. hb. cn
:027282778580 ,E2mail : acjpe 077 @public. wh. hb. cn
Moldoon M , Stanker LH. Molecularly imprinted solid phase
Andersson LI , Paprica A ,Arvidsson T. A highly selective
extraction of atrazine from beef liver exracts [ J ] . Anal
solid phase extraction sorbent for pre2concentration of
Chem , 1997 , 69 (3) :803 - 808.
sameridine made by molecular imprinting[J ] . Chromatogra2
Matsui J , Okada M , Tsoruoka M , et al . Solid2phase ex2
phy , 1997 , 46 (1/ 2) :57 - 62.
traction of atrazine herbicide using a molecularly imprinted
Hosoya K , Shirasu Y , Kimata K , et al . Molecularly im2
synthetic receptor[J ] . Anal Commun , 1997 , 34 (3) :85 -
printed chiral stationary phase prepared with racemic tem2
plate[J ] . Anal Chem , 1998 , 70 (5) :943 - 945.
Zander A , Findlay P , Renner T , et al . Analysis of nicotine
Kempe M , Glad M , Mosbach K. An approach towards sur2
and its oxidation products in nicotine chewing gum by a
face imprinting using the enzyme ribonuclease A[J ] . J Mol
molecularly imprinted solid2phase extraction [ J ] . AnalRecognit , 1995 , 8 (1/ 2) :35 - 39. Chem , 1998 , 70 (15) :3304 - 3314.
Piletsky SA , Andersson HS. The rational use of hydrophobic
Cormack PAG , Mosbach K. Molecular imprinting : recent
effect2based recognition in molecularly imprinted polymers
development and the road ahead [J ] . React Funct Polym ,
[J ] . J Mol Recognit , 1998 , 11 (1 - 6) :94 - 97. 1994-2008 China Academic Journal Electronic Publishing House. All rights reserved. http://www.cnki.net
Special Article Accepted: April 30, 2009 Published online: August 27, 2009 Psychosomatic Assessment Giovanni A. Fava a, d Nicoletta Sonino b–d a Department of Psychology, University of Bologna, Bologna , and Departments of b Statistical Sciences and c Mental Health, University of Padova, Padova , Italy; d Department of Psychiatry, State University of New York Key Words the
DIRECTIVE CLINIQUE DE LA SOGC DIRECTIVE CLINIQUE DE LA SOGC Prise en charge conservatrice de l’incontinence urinaire Résultats : Des recherches ont été menées dans la Cochrane Library La présente directive clinique a été examinée et approuvée par le et Medline afin d’y trouver les articles, publiés entre 1966 et 2005, comité exécutif et le Conseil de la Société d