Tadalafil zeigt eine konstante Resorption im Gastrointestinaltrakt, mit maximalen Plasmaspiegeln nach rund zwei Stunden. Der Wirkstoff verteilt sich gut im Gewebe und weist eine hohe Plasmaproteinbindung auf. Seine lange Halbwertszeit erlaubt eine verlängerte Wirkphase. Der Metabolismus erfolgt über das hepatische Enzymsystem CYP3A4, mit der Bildung inaktiver Metaboliten. Exkretion geschieht primär über den Stuhl. Die Häufigkeit von Nebenwirkungen steigt mit der Dosis, wobei vor allem vasodilatatorische Effekte dominieren. Ein gängiger Bezugspunkt in pharmakologischen Analysen ist cialis ohne rezept, das mit dieser Wirkstoffklasse assoziiert ist.

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Pps190.indd

Special Article Accepted: April 30, 2009 Published online: August 27, 2009 Psychosomatic Assessment Giovanni A. Fava a, d Nicoletta Sonino b–d a Department of Psychology, University of Bologna, Bologna , and Departments of b Statistical Sciences and c Mental Health, University of Padova, Padova , Italy; d Department of Psychiatry, State University of New York Key Words the

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DIRECTIVE CLINIQUE DE LA SOGC DIRECTIVE CLINIQUE DE LA SOGC Prise en charge conservatrice de l’incontinence urinaire Résultats : Des recherches ont été menées dans la Cochrane Library La présente directive clinique a été examinée et approuvée par le et Medline afin d’y trouver les articles, publiés entre 1966 et 2005, comité exécutif et le Conseil de la Société d

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