Swanlund Administration Building, MC 304
Honorary Doctor of Science Degree, Swarthmore College
Postdoctoral Fellow, University of Michigan
Administrative Positions 2011-present Chancellor,
University of Illinois at Urbana-Champaign and Vice President,
Interim President, University of Washington
Provost and Executive Vice President, University of Washington
Provost and Vice President for Academic Affairs, University of Washington
Dean of the College/Division of Biological Sciences, University of California Davis
Chair of the Department of Physiology, College of Medicine, University of Kentucky
Faculty Positions 2011-
Professor of Molecular and Cellular Biology (College of Liberal Arts and Sciences); Professor of Animal Sciences (College of Agricultural, Consumer, and Environmental Sciences); Professor of Medical Molecular and Integrative Physiology and Obstetrics and Gynecology (College of Medicine)
Professor of Physiology and Biophysics, and Obstetrics and Gynecology (School of Medicine) and Biology (College of Arts and Sciences), University of Washington
Distinguished Professor of Neurobiology, Physiology and Behavior (Division of Biological Sciences) and Physiology and Membrane Biology (School of Medicine), University of California Davis
Professor and Chair, Department of Physiology, College of Medicine, University of Kentucky, Lexington
Professor, Department of Physiology, School of Medicine, University of Maryland Baltimore
Associate Professor, Department of Physiology, School of Medicine, University of Maryland
Department of Physiology, School of Medicine,
Adjunct Assistant Professor, Department of Physiology, School of Medicine, and Lecturer, Department of Biology, University of New Mexico
Research Associate, Department of Physiology, School of Medicine, University of New Mexico
Honors and Awards (2001-2011) 2012
Asian Pacific Americans in Higher Education Award for leadership
Chang-Lin Tien Educational Leadership Award
Association of Chairs of Departments of Physiology Service Award
Member of the National Academy’s Institute of Medicine
Fellow of the American Association for the Advancement of Science
Roy O. Greep Award for Excellence in Endocrine Research
National Institutes of Health, MERIT Award
Major Administrative Accomplishments
Chancellor, University of Illinois at Urbana-Champaign
Undertook a “Big Vision” exercise to put into action themes that emerged from the VFE
initiative. We are in the midst of writing a strategic plan to guide decisions over the next decade.
Completed a “Visioning Future Excellence” (VFE) initiative to tackle two questions: What will
be the major societal challenges 20-50 years from now? What will the role of the University of Illinois, a major public research university, be to develop solutions to these challenges?
Completed a “listening and learning tour” to meet faculty, students and staff in order to learn
about the strengths and challenges facing the campus
Completed and distributed the outcomes of “Stewarding Excellence”
Successfully recruited a new Provost, Vice Chancellor for Research, Vice Chancellor for
Institutional Advancement, Athletic Director, and Chief of Police
Led a “Transformative Leadership” retreat, which brought together the mayors of Urbana
and Champaign, and other community leaders with members of the UIUC community to develop an action plan to work together to lead to an even better, more sustainable and more healthy community and university.
Interim President, University of Washington
Traveled the state on a “listening and learning tour” to meet donors, business and
foundation partners, and government leaders to understand their sense of the UW’s strengths and weaknesses.
Continued a major planning initiative (2 years to 2 decades) to ensure that our near-term
resource decisions align with our long-term strategic priorities. This includes developing a “sustainable academic business plan.”
Consulted with over 3000 faculty, students, staff, UW Foundation members, Alumni
Association leaders to develop long-term strategic priorities that guide near-term decisions.
Advocated strongly with legislators and Governor for legislation tuition delegating authority,
greater autonomy from state regulations, and flexibility in capital planning to the UW.
Continued active program to deepen relationships with friends and donors. Gifts from
donors this year were the second highest in the history of the UW.
Provost and Executive Vice President, University of Washington
Created the College of the Environment to consolidate and build upon one of the world’s
strongest constellations of environmental talent. The College of the Environment has the largest number of faculty and students, and the highest grants and contracts revenue of any in the world. Recruited the inaugural dean.
Recruited 12 new deans and two chancellors. Regularly attracted our top choices because
of UW’s culture of strong collaborative leadership. Reorganized the Provost’s Office, appointing 10 vice provosts. Over half of these appointments are under-represented minorities and/or women.
Launched Activity Based Budgeting (ABB), a new transparent model of budgeting, which
recognizes the true costs of instruction and research.
Established and secured funding for the “Husky Promise” scholarship program. This
program guarantees that full tuition and standard fees will be paid for up to 4 years to qualified in-state undergraduate students.
Established the Office for Global Affairs to enhance faculty and students interactions with
universities, research institutes, government and businesses internationally.
Founded a UW China office to enhance interaction with our Chinese counterparts in
educational, research, and industrial settings in China.
Oversaw creation of a campus-wide UW vision statement and core values. Tasked a committee to review ways to enhance the undergraduate learning experience,
leading to more centralized and coordinated delivery of student services.
Serve as principal investigator on several federal grants to enhance opportunities for junior
faculty to further their careers, establish networks, and identify and mentor new leaders. Serve as principal investigator on federal grants to increase the number and the success of students of color in science, technology, engineering and math.
Dean of the College of Biological Sciences, University of California Davis
Led the change in the designation of the Division of Biological Sciences to the College of
Biological Sciences, which clarified the stature and role in the university.
Oversaw expansion of extramural funding in the Division of Biological Sciences by 50% over
Chaired Council of Life Sciences Deans (Deans of the Schools of Medicine and Veterinary
Medicine, the Colleges of Agricultural and Environmental Sciences and Engineering, and the Divisions of Mathematical and Physical Sciences, Social Sciences, and Biological Sciences). Initiated and promoted campus-wide initiatives in the life sciences, coordinated funding of these initiatives, and provided advice to the Provost.
Led the first major reform of the undergraduate curriculum in over 10 years and initiated an
Led the development of a five-year (2005-2010) academic/strategic plan that embodied a
vision of the Division’s unique role at UC Davis.
Developed plans for a $105 million Neuroscience Building.
Oversaw the building of the Genome and Biomedical Sciences Building and the Sciences
Laboratory Building, which opened in July 2005.
Selected National Service (2001-2013)
Served on numerous advisory and professional society boards and currently serve on the NIKE Board of Directors, RAND Health Advisory Board, American Academy of Arts and Sciences’ Lincoln Project, , RWJ Committee on the Future of Nursing, Big Ten Presidents and Chancellors Committee, NCAA Minority Opportunities and Interests Committee, Governor Quinn’s Export Advisory Council, ACE Committee on Inclusion, Donald Danforth Plant Science Center Board, St. Louis Science Center Board of Trustees . Research Accomplishments
Funded continuously by the NIH for 32 years (1980-2012) including two ten-year grants (MERIT awards). Research focuses on:
- Neural and endocrine mechanisms that regulate neural plasticity during aging, with
particular emphasis on their impact on the female reproductive system
- Neuroprotective actions of estrogen after injury and during aging
Principal investigator on NIH training grants, program projects and center grants and NSF grants that support the collaborations of multiple investigators, with a focus on funding that supports under- represented and women students and junior faculty. Primary mentor of over 25 pre- and post-doctoral fellows, most of whom are faculty or leaders in health related industries. Publications Published over 120 articles in refereed journals and 75 invited review articles. Articles in Refereed Journals (2001-2012) Downs JL, Gerhold LM, Wise PM 2013 Attenuated estradiol-mediated KiSS1 drive from the anteroventroperiventicular (AVPV) nucleus during female reproductive aging. Submitted Rutkowsky JM, Wallace BK, Wise PM, O’Donnell ME 2011 Effects of estradiol on ischemic factor- induced astrocyte swelling and AQP4 protein abundance. American Journal of Physiology 391:C204-212 Brown CM, Becker JO, Wise PM, Hoofnagle AN 2011 Simultaneous determination of 6L-arginine metabolites in human and mouse plasma by using hydrophilic-interaction chromatography and electrospray-tandem mass spectrometry in human and mouse plasma and serum. Clinical Chemistry 57:701-709 Brown CM, Mulcahey TA, Filipek NC, Wise PM 2010 Production of proinflammatory cytokines and chemokines during neuroinflammation: novel roles for estrogen receptors alpha and beta. Endocrinology 151:4916-4925 Lam TI, Wise PM, O’Donnell MA 2009 Cerebral microvascular endothelial cell Na/H exchange; evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin. American Journal of Physiology 297:C278-289
Brown CM, Dela Cruz CD, Yang E, Wise PM 2008 Inducible nitric oxide synthase and estradiol exhibit complementary neuroprotective roles after ischemic brain injury. Experimental Neurology 210:782-787 Suzuki S, Gerhold LM, Böttner M, Rau SW, DelaCruz, C, Yang E, Zhu H, Yu J, Cashion AB, Kindy MS, Merchenthaler I, Gage FH, Wise PM 2007 Estradiol enhances neurogenesis following ischemic stroke through estrogen receptors and . Journal of Comparative Neurology 500:1064-1075
Suzuki S, Brown CM, Dela Cruz, C, Yang E, Bridwell D, Wise PM 2007 Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and anti-inflammatory actions. Proceedings of the National Academy of Science 104:6013-6018 Jelks KAB, Wylie RL, Floyd CL, McAllister AK, Wise PM 2007 Estradiol targets synaptic proteins to induce glutamatergic synapse formation in cultured hippocampal neurons: critical role of estrogen receptor-α . Journal of Neuroscience 27:6903-6913 Böttner M, Dubal DB, Rau SW, Suzuki S, Wise PM 2006 Stroke injury in rats causes an increase in Activin A gene expression which is unaffected by oestradiol treatment. Journal of Neuroendocrinology 18:97-103
Gerhold LM and Wise PM 2006 Vasoactive intestinal polypeptide regulates dynamic changes in astrocyte morphometry: Impact on gonadotropin releasing hormone neurons. Endocrinology 147:2197-2202 Dubal DB, Rau SW, Shughrue PJ, Zhu H, Yu J, Cashion AB, Suzuki S, Gerhold LM, Böttner M, Dubal SB, Merchenthaler I, Kindy M, Wise PM 2006 Differential modulation of estrogen receptors (ERs) in ischemic brain injury: a novel role for ERα in estradiol-mediated protection against programmed cell death. Endocrinology 147:3076-3084 Gerhold LM, Rosewell KL, Wise PM 2005 Suppression of vasoactive intestinal polypeptide in the suprachiasmatic nucleus leads to aging-like changes in cAMP rhythms and activation of gonadotropin releasing hormone neurons. Journal of Neuroscience 25:62-67 Turgeon JL, McDonnell DP, Martin KA, Wise PM 2004 Hormone therapy: physiological complexity belies their therapeutic simplicity. Science 304:1269-1273 Cashion AB, Smith MJ, Wise PM 2004 Glutamic acid decarboxylase 67 (GAD67) gene expression in
the rostral preoptic area (rPOA) changes during the estrous cycle and with age. Journal of Neuroendocrinology 16:711-716
Cashion AB, Smith MJ, Wise PM 2003 The morphometry of astrocytes in the rostral preoptic area (rPOA) exhibits a diurnal rhythm on proestrus: relationship to the LH surge and effects of age. Endocrinology 144:274-280 Krajnak K, Rosewell KL, Duncan M, Wise PM 2003 Aging, estradiol and time of day differentially affect serotonin transporter binding in the central nervous system of female rats. Brain Research 990:87-94 Rau SW, Dubal DB, Böttner M, Wise PM 2003 Estradiol differentially regulates c-Fos after focal cerebral ischemia. Journal of Neuroscience 23:10487-10494
Rau SW, Dubal DB, Böttner M, Gerhold LM, Guttmann RP, Wise PM 2003 Estradiol attenuates markers of programmed cell death after focal cerebral ischemia. Journal of Neuroscience 23:11420-11426 Wilson ME, Rosewell KL, Kashon ML, Shughrue PJ, Merchenthaler I, Wise PM 2002 Age differentially influences estrogen receptor- (ER) and estrogen receptor-β (ERβ) gene expression in specific regions of the rat brain. Mechanisms of Ageing and Development 123:593-601 Wilson ME, Liu Y, Wise PM 2002 Estradiol enhances Akt activation in cortical explant cultures following neuronal injury. Molecular Brain Research 102:88-94
Dubal DB, Wise PM 2001 Neuroprotective effects of estradiol in middle-aged female rats. Endocrinology 142:43-48 Krajnak K, Rosewell KL, Wise PM 2001 Fos induction in gonadotropin releasing hormone (GnRH) neurons receiving vasoactive intestinal polypeptide (VIP) innervation is reduced in middle-aged female rats. Biology of Reproduction 64:1160-1164 Dubal DB, Zhu H, Yu J, Rau SW, Shughrue PJ, Merchenthaler I, Kindy MS, Wise PM 2001 Estrogen receptor , not , is a critical link in estradiol-mediated protection against brain injury. Proceedings of the National Academy of Science, USA 98:1952-1957 Turchan JT, Anderson C, Hauser KF, Sun Q, Zhang J, Liu Y, Wise PM, Kruman I, Maragos W, Mattson MP, Booze RM, Nath A 2001 Estrogen protects against HIV proteins, methamphetamine and cocaine. BMC Neuroscience 2:3 Smith MJ, Wise PM 2001 Neurotensin gene expression increases during proestrus in the rostral preoptic nucleus: potential for direct communication with GnRH neurons. Endocrinology 142:3006- 3013 Le W-W, Wise PM, Hoffman GE 2001 Parallel declines in fos activation of the medial anteroventral periventricular (AVPv) nucleus and LHRH neurons in middle-aged rats. Endocrinology 142:4976- 4982 Kwong K, Wu Z-X, Kashon ML, Krajnak KM, Wise PM, Lee L-Y 2001 Chronic smoking enhances tachykinin synthesis and airway responsiveness in guinea pigs. American Journal of Respiratory Cell and Molecular Biology 25:299-305 Smith MJ, Wise PM 2001 Localization of kappa-opioid receptors in oxytocinergic neurons in the paraventricular and supraoptic nuclei. Brain Research 898:162-165 Chapters and Reviews (2001-2012)
Wise PM, Brown CM, Downs JL 2012 Estrogens: protective or risk factors in the injured brain. Dialogues in Clinical Medicine. In Press Wise PM, Suzuki S, Brown CM 2009 Estradiol: a hormone with diverse and contradictory neuroprotective actions. Dialogues in Clinical Neuroscience 11:297-304 Suzuki S, Brown CM, Wise PM 2009 Neuroprotective effects of estrogens following ischemic stroke. Frontiers in Neuroendocrinology 30:201-211
Brown CM, Suzuki S, Jelks KAB, Wise PM 2009 Estradiol is a potent protective, restorative and trophic factor after brain injury. Seminars in Reproductive Medicine 27:240-249 Downs JL, Wise PM 2009 The role of the brain in female reproductive aging. Molecular and Cellular Endocrinology 299:32-38 Wise PM 2008 Clearing estrogen’s bad name. The Scientist 22:40-44 Turgeon JL, Carr MC, Maki PL, Mendelsohn ME, Wise PM 2006 Broad and complex actions of steroids in adipose, the cardiovascular system, and brain: insights derived from basic science and clinical studies. Endocrine Reviews 27:575-605 Wise PM 2006 Estrogen therapy: Does it help or hurt the adult and aging brain. Insights derived from animal models. Neuroscience. 138:831-836 Suzuki S, Brown CM, Wise PM 2006 Mechanisms of neuroprotection by estrogen. Endocrine 2:209-216 Wise PM, Dubal DB, Rau SW, Brown CM, Suzuki S 2005 Are estrogens protective or risk factors in brain injury and neurodegeneration? Re-evaluation after the Women’s Health Initiative. Endocrine Reviews 26:308-312 Wise PM 2005 Female reproductive aging. In: Biology of Aging (Masoro EM, Austad S, eds) Chapter 21. Wise PM 2005 Estrogens and cerebrovascular stroke: What do the animal models tell us? (Singh M, Simpkins JW, eds) Annals of the New York Academy of Science 1052:225-232 67. Wise PM, Cashion AB, Gerhold LM 2004 Neuroendocrine modulation and its role in the menopause. In: Hormones, Age and Cancer (Berstein LM, ed) pp 94-111 Wise PM 2003 Estrogens: protective or risk factors in brain function? Progress in Neurobiology 69:181-191 Bellino FL, Wise PM 2003 Non-human primate models of the menopause workshop. Biology of Reproduction 68:10-13 Wise PM 2003 Neuroprotective actions of estradiol in brain injury. Endocrine 21:11-15 Wise PM, Dubal DB 2003 Are estrogens protective or risk factors in the brain: insights derived from animal models. In: Endocrine Aspects of Successful Aging: Genes, Hormones and Lifestyles. (Chanson P., Epelbaum J, Lamberts S, Christen Y, eds) Springer pp165-174 Wise PM, Dubal DB, Rau SW, Cashion AB 2003 Mechanisms of sex-based neuropathologies. In: Principles of Sex-Based Physiology (Miller VM, ed) pp 281-294 Wise PM 2003 Aging of the reproductive system. In: Physiological Basis of Aging and Geriatrics. (Timiras PS, ed) Third Edition CRC Press pp 189-212 Wise PM 2002 Estrogen and neuroprotection. Trends in Endocrinology and Metabolism 13:229-230
Wise PM, Smith MJ, Dubal DB, Wilson ME, Rau SW, Cashion AB, Böttner M, Rosewell KL 2002 Neuroendocrine modulation and repercussions of female reproductive aging. Recent Progress in Hormone Research 57:235-256 Wise PM, Smith MJ 2002 Aging of the female reproductive system. In: Springer Encyclopedia of Aging. (Maddox G, ed) Third Edition Springer Verlag. 1:392-394 Dubal DB, Wise PM 2002 Estrogen and neuroprotection: from clinical observations to molecular mechanisms. Dialogues in Clinical Neuroscience: CNS Aspects of Reproductive Endocrinology 4:149-162 Wise PM, Dubal D, Wilson ME, Rau SW, Liu Y 2001 Estradiol: A trophic and protective factor in the adult brain. Frontiers in Neuroendocrinology 22:33-66 Wise PM and Smith MJ 2001 Neuroendocrine aspects of female reproductive aging. (Hof PR and Mobbs CV eds) In: Functional Neurobiology of Aging. Academic Press, San Diego pp 795-806 Wise PM, Dubal DB, Wilson ME, Rau SW, Böttner M 2001 Neuroprotective effects of estrogen: new insights into mechanisms of action. Endocrinology 142:969-973 Wise PM 2001 Estradiol: a protective factor in the adult brain. Journal of Pediatric Endocrinology and Metabolism 13:1425-1430 McEwen BS, Wise PM, Birge S 2001 Estrogens and the brain: Implications for the treatment of postmenopausal women. (Manni A, Verderame M, eds) In: Selective Estrogen Receptor Modulators: Research and Clinical Applications Human Press, Totowa, NJ pp121-146 Wise PM, Wilson ME, Dubal DB, Rau SW 2001 In vitro and in vivo approaches to the study of the neuroprotective actions of estradiol. (Handa RJ, Hayashi S, Terasawa E, Kawata M, eds) In: Neuroplasticity, Development and Steroid Hormone Action, CRC Press, NY pp 81-92 Wise PM 2001 The “menopause” and the aging brain: causes and repercussions of hypoestrogenicity. Biogerontology 2:113-115 Wise PM, Dubal DB, Wilson ME, Rau SW, Böttner M, Rosewell KL 2001 Estradiol is a protective factor in the adult and aging brain: understanding of mechanisms derived from in vivo and in vitro studies. Brain Research Reviews 37:313-319 Wise PM, Smith MJ 2001 Female reproductive system. (Maddox G, ed) In: Encyclopedia of Aging, Springer Verlag, pp 392-394
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