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PLO CREAM COMPOUNDING INSTRUCTIONS
INFORMATION FOR THE PHARMACIST
2% DEXAMETHASONE Using the DiffusiMAX® KIT

To make 100 grams of 2% DEXAMETHASONE using the DiffusiMAX Kit:
1. Clean equipment with alcohol.
2. Weigh out 2 grams of DEXAMETHASONE powder and place in a mixing vessel.
3. Make a paste by adding 5 mL of propylene glycol. Avoid using too much propylene glycol, as this will
reduce the consistency of the final product. The paste may be slightly granular.
4. If Compound A has been cooled, it may be solid. Warming to room temperature will allow it to liquify
for use. Compound B has the unusual property of solidifying at room temperature. To liquify,
refrigerate prior to use.
5. Measure 73.5 mL DiffusiMAX Compound B and gradually add it to the DEXAMETHASONE paste.

6. Measure 24.5 mL DiffusiMAX Compound A.
7. The final product can be made in an ointment jar. Add the DiffusiMAX Compound A to the
DiffusiMAX Compound B / DEXAMETHASONE mixture. Mix the two compounds until a thick cream
is produced.
8. For clean-up, wipe equipment, rinse with cold water, and then wash with detergent. Note: DiffusiMAX kits are prepackaged in the proper lipophilic:hydrophilic ratio. If you need to make a
different size prescription, use a ratio of one part Compound A (lipophilic) to three parts
Compound B (hydrophilic).
HOW SHOULD I STORE DiffusiMAX COMPOUND A AND COMPOUND B BEFORE USE?

Both Compound A and Compound B are stable at room temperature. The kit can be kept intact at room
temperature until use. Compound B is solid at room temperature, so it should be refrigerated prior to use to
allow it to liquify. It may be more convenient to separate the components of the kit, storing Compound A at
room temperature and keeping Compound B in the refrigerator.

HOW DO I STORE THE FINAL PRODUCT?

DEXAMETHASONE in PLO gel should be stored at room temperature. Cooling may liquify the final product.
If this occurs, further mixing can restore consistency. Shelf life of the DEXAMETHASONE / DiffusiMAX
product is six (6) months.
PLO CREAM COMPOUNDING INSTRUCTIONS
INFORMATION FOR THE PHARMACIST
2% DEXAMETHASONE Using DiffusiMAX® PRE-MIXED CREAM

To make 100 grams of 2% DEXAMETHASONE in DiffusiMAX pre-mixed cream:
1. Clean equipment with alcohol.
2. Weigh out 2 grams of DEXAMETHASONE powder and place in a mixing vessel.
3. Make a paste by adding 5 mL of propylene glycol. Avoid using too much propylene glycol, as this will reduce the consistency of the final product. The paste may be slightly granular. 4. Measure out required amount of DiffusiMAX pre-mixed cream (100 grams minus the weight of the drug). If the cream had previously been cooled, it may be partially liquid. Mixing will restore its proper consistency. 5. Mix the DEXAMETHASONE paste into the DiffusiMAX cream. The final product can be made in the
6. For clean-up, wipe equipment, rinse with cold water, and then wash with detergent. HOW SHOULD I STORE DiffusiMAX PRE-MIXED CREAM BEFORE USE?

DiffusiMAX pre-mixed cream is stable at room temperature and should be stored at room temperature.
Cooling may liquify the pre-mixed cream. If this occurs, further mixing can restore consistency.
HOW DO I STORE THE FINAL PRODUCT?

DEXAMETHASONE in PLO gel should be stored at room temperature. Cooling may liquify the final product.
If this occurs, further mixing can restore consistency. Shelf life of the DEXAMETHASONE / DiffusiMAX
product is six (6) months.
COMMENTS OR QUESTIONS? CONTACT US AT:
PHONE: 1-888-MAXIMA8 (629-4628) FAX: (780) 434-8513
Visit our Website: www.diffusimax.com

Source: http://www.maximapharmaceuticals.com/English/docs/dexamethasone.pdf

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