MATERIAL SAFETY DATA SHEET State of the art ingredients ∙ fast friendly service SECTION 1 :: PRODUCT IDENTIFICATION Chemical Name: Caffeine, anhydrous INCI: Caffeine SECTION 2 :: DATA ON COMPONENTS Molecular Weight: 194.19 Chemical Characterization: C2-H10-N4-O2 FEMA number: 2224 TSV Level: 10 mg/m3 Caffeine is regulated as a nuisance particulate, not otherwise classified. Hazardous Impurities: none SECTION 3 :: HAZARDS IDENTIFICATION Hazardous Material Information System (HMIS) Health: 3 Fire: 0 Reactivity: 0 Persistence: 1 Emergency Overview: Silky white crystals or crystal ine powder with bitter taste. Efflorescent. Toxic central nervous stimulant. Caffeine has been implicated in increased fetal losses and is considered a possible teratogen. Most Important Hazard: Ingestion: may cause central nervous system stimulation resulting in insomnia, restlessness, increased respiration, delirium and may effect the cardiovascular system. Carcinogen status: possible teratogen SECTION 4 :: FIRST AID MEASURES Eyes: Flush eyes with water as a precaution. If eye irritation persists, consult with a specialist. Skin: Wash off with soap and plenty of water. If skin irritation persists, cal a physician. Inhalation: Move to fresh air. If symptoms persist, cal a physician. Ingestion: If the patient is conscious, give two glasses of water and induce vomiting. Get immediate medical attention. Never give anything by mouth to an unconscious person. Protection of first-aiders: no hazards which require special first aid measures. SECTION 5 :: FIRE FIGHTING MEASURES Flash Point: not applicable Flammable limits: 2.0-16% Autoignition temperature: 925°C Extinguishing media: Water spray, dry powder, foam, carbon dioxide Fire fighting Equipment/Instructions: Do not scatter material with high pressure water streams. Dike fire control water for later disposal. Use standard procedure for chemical fire. Special protective equipment: Use personal protective equipment including self-contained breathing apparatus when fighting fire in enclosed area. 5103 Commercial Park Dr, Ste A ∙ Austin TX 7824 (512) 535::2711 ∙(512) 535::7362 fax ∙ MATERIAL SAFETY DATA SHEET State of the art ingredients ∙ fast friendly service SECTION 6 :: ACCIDENTAL RELEASE MEASURES Spill and Leak procedures Personal Precautions: Use personal protective equipment. Avoid dust formation. Environmental Precautions: Dispose according to federal, state and local authorities. Methods for cleaning up: Sweep up and shovel. After cleaning, flush away with traces of water. SECTION 7 :: HANDLING AND STORAGE Technical measures/Precautions: No special technical protective measures required. Safe handling advice: No special handling advice require Technical measures/Storage conditions: Keep tightly closed in a dry and cool place. Incompatible products: No special restrictions on storage with other products. Packaging materials: Store in original container. SECTION 8 :: EXPOSURE CONTROLS AND PERSONAL PROTECTION Engineering measures: Provide general dilute ventilation. Exposure limit(s): Threshold Limit Value: 10 mg/m3, Nuisance Particulate, N.O.C. Respiratory: NIOSH approved dust respirator Eyes: safety glasses Skin: lightweight protective clothing, gloves General: Handle in accordance with good industrial hygiene and safety practice SECTION 9 :: PHYSICAL AND CHEMICAL PROPERTIES Form: powder Color: white Odor: none Boiling point: Sublimes at 178°C Specific Gravity: 1.23 Melting point/range: 238°C Solubility in Water: g/kg ~2.5% @ 20°C 1 gm in 46 ml water Freezing Point: N/A Evaporation Rate: N/A pH value: 1% solution -6.9 % volatiles by volume: N/A Vapor Density: N/A Vapor Pressure: N/A Coefficient of water/oil distribution: N/A Decomposition temperature: unknown Bulk density: unknown Explosive properties: unknown 5103 Commercial Park Dr, Ste A ∙ Austin TX 7824 (512) 535::2711 ∙(512) 535::7362 fax ∙ MATERIAL SAFETY DATA SHEET State of the art ingredients ∙ fast friendly service SECTION 10 :: STABILITY AND REACTIVITY Chemical Stability: stable at normal conditions Conditions to avoid if unstable: N/A Incompatibility with other materials: strong acids, alkalis, oxidizers Hazardous polymerization: does not occur Hazardous decomposition products: N/A Conditions to avoid: Keep containers dry and tightly closed to avoid moisture absorption and contamination. Extreme heat may cause sublimination. SECTION 11 :: TOXICOLOGY INFORMATION Acute toxicity: LD50/Oral/Human 192 mg/Kg Chronic toxicity: Chronic caffeine effects involve the status of experimental teratogen and carcinogen. In women it has been implicated in increased fetal losses. Human experience: Acute caffeine poisoning may cause insomnia, restlessness, tremor and delirium, tachycardia and extrasystales. Carcinogen content: listed as an experimental carcinogen by NTP Additional toxicity data: R.T.E.C.S. #EV6475000, NIOSH SECTION 12 :: ECOLOGY INFORMATION Mobility: completely soluble. Persistence and degradability: Chemical oxygen demand: unknown Biochemical oxygen demand within 5 days: (BOD5) Unknown Bioaccumulation: unknown Ecotoxicity effects: unknown SECTION 13 :: DISPOSAL CONSIDERATIONS
Waste from residues/unused products: any disposal practice must be in compliance with local, state and federal laws and regulations (contact local or state environmental agency for specific rules). SECTION 14 :: TRANSPORT INFORMATION
Not a Hazardous material for DOT shipping. SECTION 15 :: REGULATIONS
Is general y regarded as safe (GRAS) by the USA FDACaffeine is not subjected to SARA section 313 reportingThe ingredients are listed on the TSCA inventory listCERCLA (Comprehensive Response Compensation and Liability Act): N/ASARA Title 311 (Superfund Amendments and Reauthorization Bil ): reporting not required under section 311
5103 Commercial Park Dr, Ste A ∙ Austin TX 7824 (512) 535::2711 ∙(512) 535::7362 fax ∙ MATERIAL SAFETY DATA SHEET State of the art ingredients ∙ fast friendly service
Foreign Inventory Status:Canadian DSL (Domestic Substance List)
SECTION 16 :: COMMENTS
The information accumulated herein is believed to be accurate but is not warranted to be whether originating with Ingredients To Die For or not. Recipients are advised to confirm in advance of need that the information is current, applicable, and suitable to their circumstances. 5103 Commercial Park Dr, Ste A ∙ Austin TX 7824 (512) 535::2711 ∙(512) 535::7362 fax ∙
Apolipoproteins and carotid artery atherosclerosis in an elderlymultiethnic population: the Northern Manhattan stroke studyJiann-Shing Jeng a, Ralph L. Sacco a,b, Douglas E. Kargman a, Bernadette Boden-Albala a,b, Myunghee C. Paik b, Jeffrey Jones c, Lars Berglund c,a Departments of Neurology, Columbia University, New York, NY, USAb School of Public Health, Columbia University, New York,
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MATERIAL SAFETY DATA SHEET
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MATERIAL SAFETY DATA SHEET