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Tretinoin (TRET I noyn)
also know as All-trans-Retinoic Acid (ATRA)
US Brand Names:
What is this medicine used for?
How does it work?
ATRA works by killing blood cells. This particular drug is used to treat acute promyelocytic
What should my doctor or nurse know before I take this medication?
If you are allergic to any medicines.
If you are taking other over-the-counter or prescription medicines, including vitamins and
How is this drug given?
This medicine can be used alone or in combination with other cancer medicine.
Avoid alcohol while taking this medication.
What are the general precautions when taking this medicine?
Talk with your doctor or nurse before taking aspirin, aspirin-containing products, over the
counter or prescription medications, including vitamins and herbal remedies.
Drink 8 to10 glasses of non-caffeinated liquid every day (unless told otherwise by your
doctor or nurse).
If you or your partner can get pregnant, use birth control during your treatment. Once completingtreatment, discuss the timing for discontinuing birth control measures with your provider. (See PatientTeaching Sheet: Fertility)
What are the common side effects of this medicine?
Retinoic acid-APL syndrome: fever, shortness of breath, weight gain, and chest pain. This
syndrome usually occurs during the first month of treatment.
Elevated cholesterol: your cholesterol level will be monitored and should decrease when
Myelosuppression (drop in number of blood cells)
Will cause a drop in the number of white blood cells in your body (Neutropenia). These
cells fight infection. A drop in the number of these cells puts you at risk for infection .
Talk to your doctor or nurse about your risk. Practice good hand washing and avoid
people with infections, colds or flu when you are at risk. (pt. teaching sheet Neutropenia)
Danger signals to report immediately to your doctor or nurse:
Signs or symptoms of infection. This includes a fever of 100.4o F (38o C) or greater, chills,
severe sore throat, ear or sinus pain, cough, increased sputum or change in color, painful
urination, mouth sores, wound that will not heal, or anal itching or pain.
Severe nausea or vomiting or diarrhea not controlled by medication.
Bleeding from your nose, mouth, gums, or in your urine or bowel movements. Bruising
Feeling extremely tired, weak, dizzy or light headed.
How should I store this oral medicine?
Keep all medicine out of reach of children & pets.
Consult your pharmacist for instructions on storage and disposal of this medication.
What do I do if I miss an oral dose?
Contact your doctor or nurse. Do not make up a skipped dose without discussing with your
This document is intended for use by staff of Stanford Hospital and Clinics. No representations or warranties are made for outside use. Not for
reproduction or publication without permission. Direct inquiries to Stanford Hospital and Clinics. 8/07;12/09;12/10.
Analgesics Fact Sheet Group 1: Traditional pain medications (called analgesics) These can be tried for usual acute pain or nociceptive pain, inflammatory pain and some of these might help neuropathic pain. Paracetamol Paracetamol is available from pharmacies as tablets, liquid mixtures, or suppositories. Often paracetamol is the sole chemical, but it is also used in o Paracetamol
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