Microsoft word - 005-guideline_bullouspemphigoid_2011.doc
target antigens dermo-epidermal junction
F (Level of evidence 1, Strength of recommendations A) F
2.3.1 Azathioprine (Level of evidence 2, Strength of recommendations B)
2.3.2 Methotrexate (Level of evidence 3, Strength of recommendations C)
2.3.3 Cyclophosphamide (Level of evidence 4, Strength of recommendations C)
2.3.4 Mycophenolate mofetil (Level of evidence 2, Strength of recommendations B)
2.3.5 Cyclosporine (Level of evidence 4, Strength of recommendations C)
2.3.6 Chlorambucil (Level of evidence 3, Strength of recommendations C)
F (Level of evidence 4, Strength of recommendations C)
2.4.1 Dapsone (Level of evidence 3, Strength of recommendations C)
2.4.2 Sulfonamides (Level of evidence 3, Strength of recommendations C) sulfapyridine
Glucose-6 phosphate dehydrogenase (G6PD) deficiency
3.1 Intravenous immunoglobulin (IVIG) (Level of evidence 3, Strength of recommendations
3.2 Plasmapheresis (Plasma exchange) (Level of evidence 2, Strength of recommendations B)
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management of bul ous pemphigoid. Br J Dermatol 2002 147: 214-21.
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bul ous pemphigoid. Cochrane Database Syst Rev 2010 Oct6; (10): CD 002292.
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oral pulse methotrexate as monotherapy in elderly patients with bul ous pemphigoid. J Am Acad Dermatol 1999; 40:741-9.
6. Itoh T, Hosokawa H, Shirai Y, Horio T. Successful treatment of bul ous pemphigoid with pulsed
intravenous cyclophosphamide. Br J Dermatol 1996; 134: 931-3.
7. Venning VA, Mil ard PR, Wojnarowska F. Dapsone as first line therapy for bul ous pemphigoid. Br
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retrospective study of thirty-six cases. J Am Acad Dermatol 1996; 34: 683-4.
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topical corticosteroids in patients with bul ous pemphigoid. N Engl J Med 2002; 346: 321-7.
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therapy of bul ous pemphigoid. Arch Dermatol 1994; 130: 753-8.
11. Morel P, Guil aume JC. Treatment of bul ous pemphigoid with prednisolone only: 0.75 mg/kg/day
versus 1.25 mg/kg/day. A multicenter randomized study. Ann Dermatol Venereol 1984; 111: 925-8.
12. Dreno B, Sassolas B, Lacour P, Montpoint S, Lota I, Giordano F, et al. Methylprednisolone versus
prednisolone methylsulfobenzoate in pemphigoid: a comparative multicenter study. Ann Dermatol Venereol 1993; 120: 518-21.
13. Piamphongsan T. Dapsone for the treatment of bul ous pemphigoid. Asain Pac J Al ergy Immunol
14. Burton JL, Harman RR, Peachey RD, Warin RP. Azathioprine plus prednisone in treatment of
15. Guil aume JC, Vail ant L, Bernard P, Picard C, Prost C, Labeil e B, et al. Control ed trial of
azathioprine and plasma exchange in addition to prednisolone in the treatment of bul ous pemphigoid. Arch Dermatol 1993; 129: 49-53.
16. Roujeau JC, Guil aume JC, Morel P, et al. Plasma exchange in bul ous pemphigoid Lancet. 1984; 2:
17. Hofmann S, Thoma-Uszynski S, Hunziker T, et al. Severity and phenotype of bul ous pemphigoid
relate to antibody profile against the NH2- and COOH-terminal regions of the BP180 ectodomain. J
18. Tsuji-Abe Y, Akiyama M, Yamanaka Y, Kikuchi T, Sato-Matsumura KC, Shimizu H. Cor elation of
clinical severity and ELISA indices for the NC16A domain of BP180 measured using BP180 ELISA kit in bul ous pemphigoid. J Dermatol Sci 2005; 37: 145-9.
19. Schmidt E, Obe K, Brocker EB, Zil ikens D. Serum levels of autoantibodies to BP180 cor elate with
disease activity in patients with bul ous pemphigoid. Arch Dermatol 2000; 136: 174-8.
Level of evidence Strength of recommendation
PUERTO RICO WATER RESOURCES AND ENVIRONMENTAL Date of the report: December 2nd , 2005 For Quarter Ending: December, 2005 Project Tittle: ‘Removal of Inorganic, Organic and Antimicrobials Contaminants from Aqueous Solutions by Waste Tire Crumb Rubber’ Name of Contact (PI): Oscar Perales-Perez Telephone : 1-787-8324040 (3087) Fax: 1-787-265-8016 E-mail: oscar@ge.uprm.edu Na