Dazed and confused how can i prevent my patient from becoming delirious when having surgery?
Dazed and Confused How can I prevent my patient from becoming delirious when having surgery? Learning Objectives
1. To identify which surgical patients are at
highest risk of becoming delirious post- operatively
2. To understand ways to prevent delirium in
Overview What is delirium?
z Acute confusional statez Disturbance of consciousness with reduced
z Develops over a short period of timez Evidence of medical cause from history,
Epidemiology
z Often seen in patients with underlying
– Up to 75% among surgical patients (Dyer Arch Int Med 1995)
Preoperative Delirium Risk Factors After Non-cardiac Surgery: Preoperative psychotropic drug use (e.g. benzos, narcotics, mood stabilizers) Cognitive Impairment Preoperative Delirium Risk Factors
Validated Clinical Prediction Rule (developed among patients > 50 undergoing elective non-cardiac surgery)
• Poor cognitive status (TIC score <30)
• Poor functional status (SAS class IV)
Preoperative Delirium Risk Factors Outcomes of Postoperative Delirium
Higher rates of discharge to long-term care or
Poor functional recovery among hip fracture pts
(Marcantonio JAGS 2000; Gustafson JAGS 1988)
Diagnosing Delirium Confusion Assessment Method (CAM)
Diagnosis of delirium if 1, 2, and either 3 or 4
Diagnosing Delirium-CAM Diagnosing Delirium- CAM
Results for Systematic Review of Delirium Screening Tools:Summary measures from all studies (9 studies):
Summary measures when CAM performed by an MD (4 studies):
Summary measures when CAM performed by an RN (3 studies):
Preventing Delirium Multi-component Prevention Strategies
3 trials involving hip fracture pts (N = 646)
Summary RR 0.75 (95% CI 0.64-0.88) NNT= 7 (95%CI 4-20) Multi-component Prevention Strategies Targeted Risk Factors Prevention Strategies High risk medications - Discontinue/minimize benzodiazepines, anticholinergics, antihistamines, merperidine - Modify/eliminate drugs to minimize drug interactions, adverse effect and redundancies Fluid and electrolyte - Restore serum lytes (Na, K, glucose) to normal limits imbalances - Detect and treat dehydration or fluid overload Malnutrition - Ensure proper use of dentures, proper positioning, assistance with eating if required, and consider supplements Multi-component Prevention Strategies Targeted Risk Factors Prevention Strategies Cognitive Impairment - Orientation protocols - Provision of clocks and calendars Functional Impairment - Early mobilization including out of bed regularly and as tolerated - Physiotherapy/Occupational therapy as needed Impaired Vision & - Appropriate use of glasses, hearing aids and adaptive equipment - If pain is an issue (especially post-op) consider standing orders for Acetaminophen rather than prn - Treatment of breakthrough pain starting with low dose narcotics; avoiding meperidine Multi-component Prevention Strategies Targeted Risk Factors Prevention Strategies Iatrogenic - D/C urinary catheters complications - Screen for urinary retention and incontinence - Skin care program - Appropriate bowel regiments Sleep Deprivation - Unit wide noise reduction strategies - Scheduling of medications/procedures to allow for proper sleep - Use of nonpharmacologic measures to promote sleep such as warm milk or herbal tea Pharmacological Prevention Options
5 trials:z Epidural vs. General anesthesia (N = 57)
z Pre-op Intrathecal Morphine vs. Saline (N = 59)
z Prophylactic Haldol vs. placebo (N= 430)
Pharmacological Prevention Options
Epidural (N=28) vs. General (N=29) Anesthesia
Pharmacological Prevention Options
Pre-op Intrathecal Morphine (N=29) vs. Saline (N=30)
Pharmacological Prevention Options Pharmacological Prevention Options Pharmacological Prevention Options
- benzodiazepines and narcotic continuously from 2000h – 0400h
Management of Delirium
assessment and multi-component, targeted management strategies
Multi-component Delirium Management Strategies
Interventions focused on - Optimizing sensory input
- Provision of familiar items and family presence
- Use of atypical antipsychotics were indicated
- Nutritional supplements where indicated
Multi-component Delirium Management Strategies
Summary WMD 3.25 days (95%CI -2.58 – 9.34)
Delirium - Clinical Bottom Line
z Limited evidence for delirium prevention and
z Evidence supports implementation of multi-
component prevention strategies (NNT = 7)
z Insufficient evidence to support use of any
What should be done for my frail surgical patient?
z Weigh risks and benefits of surgery with
z Considering using the validated clinical
prediction rule to better determine risk of delirium
z No clear evidence that drugs prevent delirium
What should be done for my frail surgical patient?
z Use multi-component management strategies
z No clear evidence that drugs alter course
z To control behavioral issues that are disturbing to patient, or
– Trial of atypical neuroleptics (after weighing the risks)
Risks with Atypical Antipsychotics
z Atypical antipsychotics have the best evidence
for use in managing the neuropsychiatric symptoms of dementia (and ?delirium)
– Increased risk of stroke (1-2% absolute increase)
– Increased risk of death (1% absolute increase)
Local Initiatives Delirium Prevention Among Hip Fracture Pts z Pragmatic KT intervention among hip fracture patients at
z Interrupted time-series designz Examining the impact of an electronic care pathway on
post-op delirium rates and associated outcomes
Future Initiatives z Part of an NCE grant application designed to promote
elder friendly acute care hospitals within Canada
z Implementation of the CAM screening tool on SCMz Geriatric-focused order sets
??? QUESTIONS???
403-944-1771jayna.holroyd-leduc@albertahealthservices.ca
http://www.mercola.com/display/PrintPage.aspx?docid=30236&Print. [ Part I, Ref. I, Part II, Ref. II, Appendix ]By Gary Null PhD, Carolyn Dean MD ND, Martin Feldman MD, Debora Rasio MD,Dorothy Smith PhD ABSTRACT A definitive review and close reading of medical peer-review journals, and government health statisticsshows that American medicine frequently causes more harm than good. The numbe
Curriculum Vitae: DARRYL I. MACKENZIE B.Sc. (Statistics), University of Otago, New Zealand, 1995D.Ap.Stat., University of Otago, New Zealand, 1998Ph.D. (Statistics), University of Otago, New Zealand, 2002PROFESSIONAL BACKGROUNDSince 1997 I have been applying statistical techniques to address questions of interest for a wide range of animal species including seabirds, grizzly bears, sea lio