Dr. j.e. dillberger, chairman
health and genetics
2011 Deerhound Health Survey Results – Part 3
results of our most recent health survey,
Table 2. Factor VII Test Results in
testing and adverse reactions to anesthesia,
the terms “male” and “bitch” when
designating dogs of a particular sex, and the terms “hound” or “Deerhound” when
referring to dogs of either or both sexes.
immediately obvious that a hound’s sex does
not influence its Factor VII genetic status.
Factor VII results are similarly distributed in
3.Serum bile acid testing for liver shunt,4.Urine nitroprusside testing for
Factor VII gene is relatively uncommon in the
Deerhound population. The results represent
398 Factor VII genes, as each of the 199 hounds has two copies of the gene. Negative
hounds had two normal genes, carriers had
Table 1 (at the end of this column) presents a
one normal gene and one mutant gene, and
Thus, there were 321 copies of the normal
gene and only 77 copies of the mutant gene in
most common health tests are those required
for CHIC certification: Factor VII testing,
echocardiogram, and urine test for cystinuria.
mutant Factor VII gene is uncommon within
the Deerhound population. One possibility is
cystinuria are discussed in some detail in the
hound’s chance of successful y reproducing, so that the gene has been “weeded out” of
the population over successive generations.
Deerhound is more likely to be tested for
Factor VII genetic status than to have had any
affects a dog’s reproductive health. However,
other kind of health test. The Factor VII test
it is possible that a mutant gene could reduce
results were provided for 199 Deerhounds,
a hound’s chances of reproducing if
and the results are summarized in Table 2.
were using genetic testing to exclude carrier
and affected dogs from the breeding pool.
There is no way to know how often this happens, although I hear about it anecdotal y.
If this practice does account for the low
effect from anesthesia, either suspected or
Deerhound population, then the strategy may
confirmed. If the answer was yes, the survey
be relatively widespread. Whether or not this
asked the person to specify the anesthetic
is a wise strategy is hard to say, since it is
associated with being a carrier or affected
Tables 5A and 5B (at the end of this column)
Table 4. Adverse Reaction to
No. of Responders
provided for 92 Deerhounds, and the results
demonstrate very clearly that cystinuria is a
trait that affects only males. None of the 34
As you can see, a male’s cystinuria test
result strongly influences his likelihood of
developing cystine stones in the urinary tract.
A male that tested negative had only a 7%
chance (3 in 44) of developing cystine stones,
confirmed. If the answer was yes, the survey
but a male that tested positive had a 79%
asked the person to specify the drug and
chance (11 in 14) of developing stones.
Table 3. Cystinuria Test Results in
Tables 7A, 7B, and 7C (at the end of this
Table 6. Adverse Reaction to Drug?
No. of Responders
experienced an unpleasant side effect from a vaccine, either suspected or confirmed. If the
answer was yes, the survey asked the person to specify the vaccine and describe the
circumstances. The survey also asked about vaccine failure.
included a vaccine against leptospirosis.
experienced an adverse reaction to a vaccine,
and three dogs were reported to have had a
leptospirosis component, and the dog was
vaccine fail, while 167 dogs were reported to
have had no problems with vaccines. Thus,
the incidence of vaccine reactions was 6% and
foods, grasses, and dust that began within
the incidence of vaccine failure was 2%.
two weeks of vaccination, but the vaccine
was not specified. And final y, two dogs
vaccine. In two of those dogs, the only effect
reportedly got Lyme disease “after vaccine,”
was “minor lab value anomalies,” but the
but the person did not specify whether or not
third dog had confusion and weakness in the
the vaccine given was against Lyme disease.
receiving a combination puppy vaccine that
The tables at the end of this column contain a lot of detail, and I expect that most people
will not read them now. They are published here for future reference, so that the details of the
various adverse reactions to anesthetic agents and drugs are available in case they are helpful for anyone whose dog has a similar problem in the future.
Dr. John E. Dillberger, P.O. Box 2118, Nashville, IN 47448-2118 (812) 988-6175
Table 1. Overview of Health Testing for Deerhounds
Type of Testing
Table 5A. Adverse Reactions to Anesthesia: Difficult Induction or Recovery
All of my Deerhounds go through an excitement phase, no
matter how slowly an injectable induction agent is
administered, whether ketamine/diazepam or propofol is used,
and with or without premedication. There are no deleterious
consequences, just thought it might be worth mentioning. That reaction is VERY rare in other breeds.
Kept under anesthesia for 5 hours (!) for a prescrotal
urethrostomy. After he came round, he was in terrible shape.
He screamed and screamed in a most harrowing way and had to
be held tightly. The screaming didn't abate for half an hour—
and probably wouldn't have abated at al had the vet not given him a huge dose of butorphenol to kill the pain and make him
drowsy. It took 3 days for him to be able to stand up unassisted.
Panic, crying, disorientation on waking up, final recovery OK 2
times, third time was death—DIC after spay during C-section,
but also difficulty waking up; don't know if anesthetic
Dog bloated (not torsed) and got torbugesic after
decompression. Seemed to be hal ucinating, was very agitated,
confused, and high heart rate for nearly a day.
Cyst removal & teeth cleaning. Slow to revive, then had periods
of distress and disorientation for approximately 12-16 hours after bringing him home.
Unspecified Hard to wake up from anesthesia.
Experienced difficulty waking after C-section. Vet determined
slight overdose of pain medication. Disoriented and weak-legged for 3 days.
Came out of anesthesia prematurely and roughly at beginning of
intrauterine fertilization. Procedure stopped. Anesthetic
Table 5B. Adverse Reactions to Anesthesia: Other Reactions
Spayed fine at 5 with torbutrol, but when used at 9 to try to take
an x-ray, she had a reaction, hyperthermia, which vet reversed. The dog survived.
Unspecified Died of MH during short surgery for eyelid cyst, no barbiturates
—sighthound-safe anesthetic, careful y monitored.
hyperthermia Unspecified Not sure of anesthetic.
Anesthetized once for testing procedure and body temperature
spiked to 105+ in very short period, despite icing of support IV and close monitoring. We declined to every have him
Unspecified Anesthetized for diagnosis purposes, and developed MH. Unsure
Way overly sedated for transcervical AI; needed multiple doses of
atropine to keep heart rate at 40bpm for several hours.
(Experienced repro vet swore it was a "greyhound" dose.)
Butorphenol Developed rapid atrial fibrillation after being given Torbugesic for
Unspecified Developed rapid Atrial Fibril ation a couple of days post surgery.
Dog was very sensitive to opiates, and they made her very
agitated. She was given them on a couple occasions, once post
surgery, and once as a sedative before an echo, and needed a reversal agent.
Unspecified Received an epidural during torsion surgery. We believe she
developed meningitis as a result of this procedure.
Adverse Reactions to Drugs: Neurological and/or Behavioral
Treated for H. pylori, and about 2.5 weeks in, she had some neuro deficits,
and became somewhat paralyzed. We eventual y realized it was metronidazole toxicity, discontinued the drug, and she recovered.
After several weeks on the drug (to treat pneumonia), dog suffered a
complete neuro-toxic event. Starting with inability to walk straight,
roaching of back, nystagmus, followed by the inability to stand up or sit upright whatsoever. He nearly died & spent several days in the ICU at the
emergency vet. Took several weeks for him to walk without stumbling.
Given for abscessed paw. Behavior became bizarre; personality changes,
seemed disoriented, almost demented, almost Alzheimer-y. Returned quickly to normal on withdrawal of the drug.
Dysphoric reaction to morphine, reversed with naloxone.
Adverse reaction (mental) after using it successful y twice before. Treated for suspected neck pain with 50 mg, three times daily—lethargic,
disoriented, walking into things. Did fine, later in summer, on a lower dose (50 mg once a day).
Increased heart rate, unsteady gait, confusion, anxiety, lasted about 2 days.
Given after a coursing col ision, after which had violent dreams and
25 mg given prior to scheduled vet visit. The dose I gave was 1/3 the dose
prescribed by the vet, yet he experienced extreme lethargy, wobbly, partial y closed third eyelids for nearly 12 hours.
Wooziness and loss of coordination.
Treated for suspected neck pain over the summer, and had a (suspected) reaction
Prescribed to help with skin condition. Caused lethargy, moodiness.
Suspected reaction to pred. Given several times; always got very depressed.
Table 7B. Adverse Reactions to Drugs: Gastrointestinal
Dog was being treated for stomach problems. She fell and the senior vet in
the practice saw her and decided to treat her for what he perceived to be a
spine ailment. He gave her Deramaxx without looking at her chart. Within a
few days she was bleeding internally and had to be euthanized because it could not be repaired.
Overdose of piroxicam (Feldene) from primary vet (at that time), resulting in GI
ulceration (also acute renal failure).
Treated pain for a perineal hernia and the vet switched between 2 different
NSAIDs without a break between. Dog developed tarry stools and was hospitalized for 2 days for supportive care and meds for the bleeding.
Could not be taken for Lyme disease; refused to eat while on it.
Two dogs have been treated with Metronidazole, and both had noticeable loss
Anorexia to Baytril (believe prescribed in response to cut on foot).
Some inappetance while on Abx of various types (e.g. amoxicillin, doxycycline,
cephalexin, clavamox), which was managed by giving homeopathy (nux
vomica) before meals, using flavor enhancers (e.g. Wysong PDG). Mild diarrhea was minimized with probiotics between dosings.
Became fevered 1/2 day after having been dewormed with drontal, lost
appetite, digestive system was "down " (vomiting, very different stool) for
Table 7C. Adverse Reactions to Drugs: Other Reactions
Overdose of piroxicam (Feldene) from primary vet (at that time), resulting in
acute renal failure (also GI ulceration), resolved with ICU care.
On maintenance dose of Deramaxx (50mg/day). Cephalexin was given for
interdigtal cyst. Blood concentrations increased for urea (to 17.1 mg/dL; normal = 2.5 to 9.6 mg/dL) and creatinine (to 333 mg/dL; normal = 44 to 159 mg/dL) Saline solution given for 24 hours, and levels returned to normal after 3 days.
Severe respiratory distress within 10 min of Frontline application. After being
assured by the Deerhound list that Deerhounds do fine on Frontline, we thought it was due to something else. When the next scheduled dose did the same thing, the vet, & we, said "never again".
Given after a coursing collision, after which he experienced badly depressed
Prescribed to help with skin condition.
Severe allergic reaction to Novo-Lexin (cephalexin) being given for dermatitis.
SMT-TMZ? Sulpha antibiotic. She had a staph infection because of the
allergies. We weren't aware the drug was a sulpha. After ten days her skin/eyes went blood red. Rushed her to ER, she was very fortunate to survive.
Not symptomatic on very low doses, but normal doses caused vomiting and
diarrhea. Dog died from hemorrhagic pancreatitis, suspected but not proven to be from Rimadyl.
Suspected reaction to pred. Was given several times, and each time would
get some type of infection (respiratory, prostatitis, stomach).
Could not tolerate dissolvable stitches/sutures. Her body would simply expel
Psychopathological parameters and dexamethasone Evangelos Karanikas, Faidon Harsoulis, Ioannis Giouzepas, Ioannis Griveas, Fotis Chrysomallis Departments of Dermatology, Psychiatry and Endocrinology of Medical School of Aristotelian University of Thessaloniki, Greece logical development.1 Numerous studies have attempted toidentify a specific personality profile of a representative psori- Intro
Management of postpolio syndrome Henrik Gonzalez, Tomas Olsson, Kristian Borg Lancet Neurol 2010; 9: 634–42 Postpolio syndrome is characterised by the exacerbation of existing or new health problems, most often muscle weakness See Reﬂ ection and Reaction and fatigability, general fatigue, and pain, after a period of stability subsequent to acute polio infection. Diagnosis