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Comparison of neuroprotective and neurorescue capabilities of rasagiline and
selegiline, against lactacystin induced nigrostriatal degeneration
Wen Zhu, Tianhong Pan, Wenjie Xie, Pingyi Xu, Joseph Jankovic,
Moussa B.H. Youdim, Weidong Le
Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
Department of Pharmacology, Eve Topf Center of Excellence for Neurodegenerative Diseases Research, Haifa, Israel
capabilities of rasagiline or selegiline
(p<0.01) and about 30% inhibition ofproteasomal
evident in ipsilateral SN (Fig.1, 2, 3). A
tests since the 7th day after lactacystin
animals were sacrificed (Fig. 5, 6) .
Pretreatment with rasagiline or selegiline
selegiline against nigrostriatal deficiency
and 34.3%, respectively (p < 0.01).
Comparatively, only rasagiline but not
activation with equal potency (Fig. 4).
variety of insults in both in vitro and in
against lactacystin-induced inhibition of
study, we explored and compared theneuroprotective
failure, while rasagiline is more potent.
the proteasome inhibitor, lactacystin.
properties require further investigation.
volume) into medial forebrain bundle(MFB).
Fig.3 Proteasome activity in ventral midbrain
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generarion and nigrostriatal deficiencyinduced by lactacystin were indicatedby immunostaining of TH-positive cellsand HPLC assay of DA and itsmetabolites.
CD11b-positive cells were introducedto indicate the microglial activationafter microinjection of lactacystin.
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